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Homo sapiens

ABSTRACT: Transcriptome analysis of human acute myeloid leukemia cell line MV4-11

PROVIDER: PRJDB18678 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR590904_1.fastq.gz	Fastqsanger.gz
	DRR590904_2.fastq.gz	Fastqsanger.gz
	DRR590905_1.fastq.gz	Fastqsanger.gz
	DRR590905_2.fastq.gz	Fastqsanger.gz
	DRR590906_1.fastq.gz	Fastqsanger.gz

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Gene expression changes in MV4-11 cells upon SMARCA4 knock-down and PFI-3 treatment

Project description:Pharmacological inhibition of the SMARCA4 bromodomain inhibited human leukemic cell proliferation, phenocopying SMARCA4 knockdown in these cells. We performed microarray analysis of global gene expression changes in MV4-11 cells after 6 days of PFI-3 treatment and after SMARCA4 knock-down. With this analysis we identified several genes whose expression was similarly up- or down-regulated upon inhibitor treatment and SMARCA4 depletion. Human acute monocytic leukemia cells (MV4-11, ACC 102) were lentivirally transduced with shRNA taregting SMARCA4 (KD) or with a negative control shRNA (Scr). In a parallel experiment MV4-11 cells were treated for 6 days with 10 uM PFI-3, which is SMARCA4, SMARCA2 and PBRM1 bromodomain inhibitor, or DMSO as a negative control. All sample types were prepared in triplicates.

2015-07-12 | E-GEOD-67920 | biostudies-arrayexpress

Homo sapiens

Project description:Expression data from cultured human acute megokaryblastic myeloid leukemia and acute myeloid leukemia cell lines

| PRJNA385565 | ENA