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Drosera rotundifolia strain:R1 isolate and L1 isolate

ABSTRACT: Drosera rotundifolia genome and transcriptome

PROVIDER: PRJDB18922 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR614007_1.fastq.gz	Fastqsanger.gz
	DRR614008_1.fastq.gz	Fastqsanger.gz
	DRR614009_1.fastq.gz	Fastqsanger.gz
	DRR614010_1.fastq.gz	Fastqsanger.gz
	DRR614802_1.fastq.gz	Fastqsanger.gz

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Sustainable Utilization of Rewetted Peatlands: Drosera rotundifolia L. as a Traditional Medicinal Plant for Developing New Phytopharmaceuticals Against Biofilm-Forming Multidrug-Resistant E. coli

Project description:Peatlands play a crucial role in global climate protection as carbon sinks and their rewetting is increasingly significant but poses economic challenges for agriculture. A promising application for rewetted peatlands is the cultivation of Drosera rotundifolia L., a medicinal plant with potential for sustainable phytopharmaceutical development. The plant's bioactive compounds, particularly flavonoids and naphthoquinones, exhibit biofilm-inhibiting properties against multidrug-resistant, ESBL-producing E. coli strains, offering new therapeutic options. This study investigates the molecular mechanisms of these compounds in biofilm inhibition through proteomic analyses. Specific fractions of flavonoids and naphthoquinones, as well as individual substances like 7-methyl juglone and 2’’-O-galloyl hyperoside, are analyzed. Results show that flavonoids from Drosera rotundifolia L. likely affect biofilm formation by creating an iron-poor environment through iron complexation and additionally influence polyamine balance, reducing intracellular spermidine levels. Further investigations include assays for iron complexation and analysis of polyamines confirmed the proteomic data. In-silico docking studies identify potential molecular targets of the bioactive compounds. Safety evaluations through cytotoxicity tests in 3D cell cultures and the Galleria mellonella in-vivo model confirmed the safety of the extracts used. These findings highlight Drosera rotundifolia L. as a promising candidate for new phytopharmaceuticals and support the sustainable use of rewetted peatlands.

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