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Unidentified

ABSTRACT: Early diagnosis and treatment of colitis associated colorectal cancer using microRNA 133s (KAP230602)

PROVIDER: PRJDB19460 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR676037_1.fastq.gz	Fastqsanger.gz
	DRR676037_2.fastq.gz	Fastqsanger.gz
	DRR676038_1.fastq.gz	Fastqsanger.gz
	DRR676038_2.fastq.gz	Fastqsanger.gz
	DRR676039_1.fastq.gz	Fastqsanger.gz

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Project description:Chronic inflammation of the intestine has been associated with an elevated risk of developing colorectal cancer. Recent association studies have highlighted the role of genetic predisposition in the etiology of colitis and started to unravel its complexity. However, the genetic factors influencing the progression from colon inflammation to tumorigenesis are not known. We used Helicobacter hepaticus-induced colitis in a 129.RAG(-/-) mouse model to explore early onset of the disease. Experiments purpose and justifications: to elucidate early genes and pathways changed in the mouse strain susceptible to innate colitis triggered by Hh infection. Experimental factors: steady state, and days 2 and 4 of infection (n=4 mice per condition). The time course is validated on the same samples using qPCR for inflammatory genes. Samples: RNA from proximal mouse colon. Two mouse genetic strains are compared 129Rag-/- (susceptible) and 129.R17Rag-/- (protected from colitis).

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Project description:Microarray for colorectal cancer (CBX205)

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