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Unidentified

ABSTRACT: in vivo effect of RORb Gene Silencing (KAP230671)

PROVIDER: PRJDB19493 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR678131_1.fastq.gz	Fastqsanger.gz
	DRR678131_2.fastq.gz	Fastqsanger.gz
	DRR678132.fastq.gz	Fastqsanger.gz
	DRR678132_1.fastq.gz	Fastqsanger.gz
	DRR678132_2.fastq.gz	Fastqsanger.gz

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Project description:in vivo effect of NRL Gene Silencing (KAP230672)

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Transcription profiling of mouse retina from four genotypes: +/+, Rorb-/- , +/+;CrxpNrl and Rorb-/-;CrxpNrl at P14 and P28

Project description:Rorb is essential for rod photoreceptor development in the mouse retina. Using Affymetrix mouse GeneChips, we have generated expression profiles of the +/+, Rorb-/- , +/+;CrxpNrl and Rorb-/-;CrxpNrl retina at P14 and P28. In this dataset, we include the expression data obtained from retina of wt and mutants. These data are used to obtain 1189 genes that are differentially expressed in Rorb-/- vs wt. Experiment Overall Design: 31 total samples were analyzed

2009-10-23 | E-GEOD-16585 | biostudies-arrayexpress

Expression profiling of P14 and P28 mouse retina from 4 genotypes: +/+, Rorb-/- , +/+;CrxpNrl and Rorb-/-;CrxpNrl

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Cortical RORb is required for layer 4 transcriptional identity and barrel integrity

Project description:RNA-seq and ATAC-seq from layer 4 cortical neurons expressing RORb-gfp or GFP in an RORb KO.

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An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response

Project description:We have identified and characterized an allelic series of spontaneous Rorb mutations in mice We perform RNASeq to identify gene expression changes associated with Rorb mutations in brain and spinal cord from all five mutant strains. We also perform CNS region-specific RNASeq in the Rorbh5/h5 mutant.

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Project description:Investigation of health functionalities of kimchi probiotics in vivo (KAP220299)

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Project description:Silencing of HAI-1 in a human oral squamous cell carcinoma cell line, SAS (CBX248)

| PRJDB20129 | ENA

RORb modulates a gene program that is protective against articular cartilage damage

Project description:Osteoarthritis (OA) is the most prevalent chronic joint disease which increases in frequency with age eventually impacting most people over the age of 65. OA is the leading cause of disability and impaired mobility, yet the pathogenesis of OA remains unclear. Treatments have focused mainly on pain relief and reducing joint swelling. Currently there are no effective treatments to slow the progression of the disease and to prevent irreversible loss of cartilage. Here we demonstrate that stable expression of RORb in cultured cells results in alteration of a gene program that is supportive of chondrogenesis and is protective against development of OA. Specifically, we determined that RORb regulates the balance of FGFRs signaling on FGFR1/FGFR3 that ERK1/2-MAPK signaling was suppressed by FGFR1(cartilage destruction) and AKT signaling was enhanced by FGFR3 (cartilage protection). These results suggest a critical role for RORb in chondrogenesis and suggest that identification of mechanisms that control the expression of RORb in chondrocytes could lead to the development of disease modifying therapies for the treatment of OA

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Project description:Development of macular degeneration treatment technology by inducing direct conversion of retinal cells in vivo (KAP220518)

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Chip-seq analyses of PPARγ bonded DNA fragments

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