Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: The identification of differentially methylated genes between hepatocytes of wild-type and ob/ob mice

PROVIDER: PRJDB20220 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	DRR639873_1.fastq.gz	Fastqsanger.gz
	DRR639873_2.fastq.gz	Fastqsanger.gz
	DRR639874_1.fastq.gz	Fastqsanger.gz
	DRR639874_2.fastq.gz	Fastqsanger.gz
	DRR639875_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Mus musculus

Project description:The identification of differentially methylated genes between hepatocytes and skeletal muscle of wild-type mice

| PRJDB15749 | ENA

Mus musculus strain:C57BL/6J wild-type and ob/ob mice

Project description:The identification of differentially expressed genes in skeletal muscle of wild-type and ob/ob mice

| PRJDB10695 | ENA

Mus musculus

Project description:The identification of differentially expressed genes in liver of wild-type and ob/ob mice at ad libitum feeding

| PRJDB15410 | ENA

Transcriptome analysis of isolated glomeruli from obese type 2 diabetic mice treated with enarodustat

Project description:We found that 18-week administration of a prolyl hydroxylase inhibitor, enarodustat, improved glucose/lipid metabolism of BTBR ob/ob mice, which is a model of obesity and type 2 diabetes mellitus. Enarodustat-treated mice also exhibited reduced albuminuria along with ameliorated glomerular epithelial and endothelial damage. In order to elucidate the mechanism of renoprotection, we performed microarray gene expression analysis of isolated glomeruli. The initial screening process revealed 8965 probes whose absolute values of log2 (BTBR ob/ob mice treated with enarodustat/BTBR ob/ob mice treated with vehicle-only) exceeded 0.5. We then compared the expression levels of those 8965 probes between BTBR ob/ob and wild-type mice to identify molecules that were likely to be involved in the pathogenesis of glomerular injury. Such analysis revealed 71 genes which were significantly up-regulated and 47 genes which were significantly down-regulated in BTBR ob/ob mice compared to wild-type mice. The genes were ranked according to their fold-change values, and the analysis presented Ccl2/Mcp1 as the second-most up-regulated gene in BTBR ob/ob mice. The expression level of Ccl2/Mcp1 increased by 24.42-fold in BTBR ob/ob compared to wild-type mice, and its expression in enarodustat-treated BTBR ob/ob mice was decreased to 0.62 of the vehicle-only treated BTBR ob/ob mice. Urinary CCL2/MCP-1 was indeed decreased in enarodustat-treated BTBR ob/ob mice. In vitro experiments also showed that enarodustat suppressed palmitate-induced CCL2/MCP-1 production in murine mesangial cells. Taken together, enarodustat is likely to confer renoprotection through regulating the expression of CCL2/MCP-1 in the glomerulus.

2020-04-17 | GSE131266 | GEO

Mus musculus

Project description:Microarray analysis of genes regulated by SHP in wild-type and ob/ob mice.

| PRJNA174860 | ENA

AHR IS A MASTER REGULATOR OF HIPPOCAMPAL-DEPENDENT MEMORY BY CONTROLLING NEUROGENESIS, DENDRITE GRANULE CELL MORPHOLOGY AND SYNAPTIC MATURATION

Project description:Identification of genes differentially expressed between hippocampus derived from wild type (WT) and Ahr-KO mice

2020-11-09 | GSE101453 | GEO

Microarray analysis of genes regulated by SHP in wild-type and ob/ob mice.

Project description:Liver gene expression was compared in wild type, SHP knockout, ob/ob, and ob/ob SHP double mutant mice.

2012-09-12 | GSE40775 | GEO

Diethylene Glycol Oligomer Squalene Derivative Improves Hepatic Metabolism and Attenuates Obesity-Related Dysmetabolism via Sirt-AMPK axis Activation

Project description:Transcriptomic analysis comprehensively revealed the metabolic improvement effects of di-SQ on the liver and white adipose tissue in ob/ob mice. Di-SQ demonstrated effects in improving inflammation and lipid metabolism in both the liver and white adipose tissue of ob/ob mice and restored the expression of genes and GO terms associated with mitochondrial respiration and glucose metabolism. The metabolic disorder observed in untreated ob/ob mice was reversed by a 42-day-di-SQ treatment, the di-SQ treated ob/ob mice showed a gene expression pattern in key metabolic pathways and processes that more closely resembles that of wild-type mice.

2024-12-10 | GSE281432 | GEO

Project description:Analysis of differentially expressed genes between transgenic lines and wild type

| PRJNA693427 | ENA

Mus musculus

Project description:Differentially expressed genes between oncogene-introduced wild-type and Atf4-/- cells

| PRJNA145731 | ENA