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Human immunodeficiency virus 1

ABSTRACT: Polymorphisms of HIV-1 integrase

PROVIDER: PRJDB3501 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR030143_1.fastq.gz	Fastqsanger.gz
	DRR030143_2.fastq.gz	Fastqsanger.gz
	DRR030144_1.fastq.gz	Fastqsanger.gz
	DRR030144_2.fastq.gz	Fastqsanger.gz
	DRR030145_1.fastq.gz	Fastqsanger.gz

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Human immunodeficiency virus 1

Project description:HIV-1 promoter single nucleotide polymorphisms are associated with clinical disease severity

| PRJNA309974 | ENA

Human immunodeficiency virus-1 targets genomic R-loops of the host for integration [DRIPc]

Project description:Although HIV-1 integration sites are considered to favor active transcription units in the human genome, high-resolution analysis of individual HIV-1 integration sites have shown that the virus can integrate in a variety of host genomic locations, including non-genic regions, challenging the traditional understanding of HIV-1 integration site selection. Here, we showed that HIV-1 targets R-loops, a genomic structure made up of DNA–RNA hybrids, for integration. HIV-1 initiates the formation of R-loops in both genic and non-genic regions of the host genome and preferentially integrates into regions of HIV-1-induced R-loops. Using a cell model that can independently control transcriptional activity and R-loop formation, we demonstrated that the presence of R-loops, regardless of transcriptional activity, directs HIV-1 integration targeting sites. We also found that HIV-1 integrase proteins bind to the host genomic R-loops. These findings provide fundamental insights into the mechanisms of retroviral integration and the new strategies of antiretroviral therapy against HIV-1 latent infection.

2024-11-05 | GSE281025 | GEO