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Helicobacter canicola strain:PAGU 1410T

ABSTRACT: Proposal of Helicobacter canicola sp. nov., previously identified as Helicobacter cinaedi, isolated from canines

PROVIDER: PRJDB5684 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR090572_1.fastq.gz	Fastqsanger.gz
	DRR090572_2.fastq.gz	Fastqsanger.gz
	DRR092854_1.fastq.gz	Fastqsanger.gz
	DRR092854_2.fastq.gz	Fastqsanger.gz
	DRR092855_1.fastq.gz	Fastqsanger.gz

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Changes in Potential Pathogenicity-Associated Proteins of Helicobacter cinaedi Upon Infection of Macrophage Cells

Project description:Helicobacter cinaedi is a spiral-shaped Gram-negative, enterohepatic bacterium classified as a conditional pathogen (pathogenicity group 2). It is known to cause bacteremia and a variety of other diseases in humans. Notably, H. cinaedi has been shown to induce changes in cell morphology, including the transition to “foam cells”, when interacting with macrophages. To uncover protein factors involved in the pathogenesis of Helicobacter cinaedi, we performed a detailed mass spectrometric analysis of the proteome of strain BAA-847. To the best of our knowledge, this is the first such comprehensive study examining the bacterium's protein profile both under standard culture conditions and after infection of M1-type macrophage cells. We identified 1,575 proteins in the H. cinaedi proteome, and of these, 109 proteins were differentially upregulated after infection of macrophage cells. For these proteins, we performed a detailed functional analysis and proposed a model to explain their potential roles during Helicobacter cinaedi infection. In addition to the known pathogenicity factors HcaA, Cdt, and AhpC, we discovered several poorly understood proteins that are involved in immune response evasion, adaptation for survival within host cells, and possess toxic or other potentially pathogenic functions. Among the differentially upregulated proteins, we found those that enable the bacterium to utilize intracellular cholesterol as a carbon source. Additionally, we identified proteins involved in a toxin injection mechanism that disrupts host cell metabolism, which may be linked to the foam cell formation induced by Helicobacter cinaedi.

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RNA-seq analysis of Helicobacter cinaedi ATCC BAA-847 under microaerobic and aerobic culture conditions

Project description:Helicobacter cinaedi is an emerging bacterial pathogen of immunosuppressed individuals. The species is traditionally thought to require an H2-enhanced microaerobic atmosphere for growth, although it can proliferate under aerobic conditions when co-cultured with epithelial monolayers or supplemented with certain metabolites (notably, L-lactate). The goal of this experiment was to assess the global transcription changes that occur in the H. cinaedi type strain (ATCC BAA-847) under various media and atmospheric conditions. These include bacterial monoculture, as well as co-culture with Caco-2 intestinal epithelial cells. In total, Illumina mRNA-seq (stranded, paired-end) was performed on H. cinaedi grown under 9 in vitro culture conditions (4-5 biologic replicates per condition).

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