Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Pungitius sinensis

ABSTRACT: Whole genome re-sequences of Japanese Pungitus sinensis

PROVIDER: PRJDB9072 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	DRR200448_1.fastq.gz	Fastqsanger.gz
	DRR200448_2.fastq.gz	Fastqsanger.gz
	DRR200449_1.fastq.gz	Fastqsanger.gz
	DRR200449_2.fastq.gz	Fastqsanger.gz
	DRR200450_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

Pungitius tymensis

Project description:Whole genome re-sequences of Japanese Pungitus tymensis

| PRJDB19931 | ENA

Pungitius tymensis

Project description:Whole genome re-sequencing of Japanese Hokkaido Pungitius

| PRJDB6917 | ENA

Pungitius pungitius

Project description:Whole genome seq of Japanese Pungitius pungitius

| PRJDB2321 | ENA

Pungitius sinensis

Project description:Pungitius sinensis Genome sequencing

| PRJNA1246968 | ENA

Pungitius sinensis

Project description:Pungitius sinensis alternate haplotype genome sequencing

| PRJNA1125299 | ENA

Pungitius sinensis

Project description:Pungitius sinensis principal haplotype genome sequencing

| PRJNA1125300 | ENA

Pungitius sinensis

Project description:Pungitius sinensis overview

| PRJNA660834 | ENA

Pungitius sinensis

Project description:Population genomics and Genome sequencing of Pungitius sinensis

| PRJNA939954 | ENA

Pungitius sinensis

Project description:De novo assembly of Pungitius sinensis

| PRJDB9071 | ENA

Clonorchis sinensis (C. sinensis) infection remodels the chromatin accessibility of hepatocellular carcinoma

Project description:Background: Liver cancer is the third deadliest type of cancer, posing a serious threat to human health. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. C. sinensis, classified as a definite group I carcinogen by the IARC (International Agency for Research on Cancer), is an important risk factor for HCC. Although many studies have shown that C. sinensis infection affects the prognosis of HCC patients, the specific mechanisms are still unclear, especially the dynamics and regulatory roles of chromatin accessibility. Results: In this study, we integrated ATAC-seq, RNA-seq, and ChIP-seq data to elucidate changes in the epigenetics of HCC after the C. sinensis infection. Many different accessibility regions (DARs) were identified both in tumors and adjacent tissue after the C. sinensis infection. Meanwhile, top TFs whose motifs were enriched in DAR were found, such as HNF4a, FOXI1, etc. Although there were slight deviations, epigenetic changes were found to be consistent with gene expression levels. We also revealed that H3K9ac, H3K4me2, H3K4me3, H3K27ac, and H3K4me1 were associated with chromatin accessibility. Importantly, we also found potential evidence that C. sinensis infection would alter the spatial structure of the HCC genome. Finally, both molecular experimental results and clinical data certified that C. sinensis infection would promote the metastasis of HCC. Conclusions: C. sinensis infection will remodel the chromatin accessibility of HCC, leading to changes in gene expression levels. This study provides conclusive evidence that C. sinensis infection alters the epigenetics of HCC.

2024-11-26 | GSE276855 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data