Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Drosophila X chromosome balancer project

ABSTRACT: Recombination generates sequence diversity among balancer chromosomes in Drosophila melanogaster

PROVIDER: PRJEB11499 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR1092790_1.fastq.gz	Fastqsanger.gz
	ERR1092790_2.fastq.gz	Fastqsanger.gz
	ERR1092800_1.fastq.gz	Fastqsanger.gz
	ERR1092800_2.fastq.gz	Fastqsanger.gz
	ERR1092810_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 136

Similar Datasets

Whole-genome sequencing and mate pair sequencing of D. melanogaster carrying second (CyO) and third (TM3) balancer chromosomes

Project description:We used a Drosophila melanogaster line (a "double balancer") carrying balancer chromosomes for both the second (CyO) and third (TM3) chromosomes. We crossed the double balancer to an isogenic wild-type "virginizer" line to obtain trans-heterozygous adults from the F1 generation. Whole-genome sequencing and mate pair sequencing were used to identify Single Nucleotide Variants (SNVs) and Structural Variants (SVs) on both chromosomes.

2019-05-02 | E-MTAB-7510 | biostudies-arrayexpress

RNA-seq in D. melanogaster carrying second (CyO) and third (TM3) balancer chromosomes

Project description:We used a Drosophila melanogaster line (a "double balancer") carrying balancer chromosomes for both the second (CyO) and third (TM3) chromosomes, and crossed it to an isogenic wild-type "virginizer" line. Trans-heterozygous adults from the F1 generation were further crossed to the wild-type parental line to obtain the pool of N1 embryos. Allele-specific RNA-seq was used to measure changes in gene expression from both chromosomes.

2019-04-24 | E-MTAB-7511 | biostudies-arrayexpress

Hi-C in D. melanogaster carrying second (CyO) and third (TM3) balancer chromosomes

Project description:We used a Drosophila melanogaster line (a "double balancer") carrying balancer chromosomes for both the second (CyO) and third (TM3) chromosomes, and crossed it to an isogenic wild-type "virginizer" line. Trans-heterozygous adults from the F1 generation were further crossed to the wild-type parental line to obtain the pool of N1 embryos. Allele-specific chromosome conformation capture (Hi-C) was used to measure changes in chromatin organization on both chromosomes.

2019-04-24 | E-MTAB-7512 | biostudies-arrayexpress

Capture-C in D. melanogaster carrying second (CyO) and third (TM3) balancer chromosomes

Project description:We used a Drosophila melanogaster line (a "double balancer") carrying balancer chromosomes for both the second (CyO) and third (TM3) chromosomes, and crossed it to an isogenic wild-type "virginizer" line. Trans-heterozygous adults from the F1 generation were further crossed to the wild-type parental line to obtain the pool of N1 embryos. Allele-specific chromosome conformation capture (Capture-C) was used to measure changes in chromatin organization on both chromosomes.

2019-04-24 | E-MTAB-7513 | biostudies-arrayexpress

Drosophila melanogaster 2nd chromosome substitution lines

Project description:Transcriptional profiling of Drosophila melanogaster 2nd chromosome substitution lines; Background chromosomes are identical across lines; 2nd chromosomes are different across line and can be homozygous or heterozygous within each line Keywords: Natural variation

2010-05-06 | GSE12191 | GEO

Drosophila melanosgaster 2nd chromosome substitution lines

2010-05-06 | E-GEOD-12191 | biostudies-arrayexpress

Hi-C in D. melanogaster carrying second (CyO) and third (TM3) balancer chromosomes

Project description:Hi-C in D. melanogaster carrying second (CyO) and third (TM3) balancer chromosomes

| PRJEB30429 | ENA

Capture-C in D. melanogaster carrying second (CyO) and third (TM3) balancer chromosomes

Project description:Capture-C in D. melanogaster carrying second (CyO) and third (TM3) balancer chromosomes

| PRJEB30290 | ENA

RNA-seq in D. melanogaster carrying second (CyO) and third (TM3) balancer chromosomes

Project description:RNA-seq in D. melanogaster carrying second (CyO) and third (TM3) balancer chromosomes

| PRJEB30279 | ENA

Ataxin-2 regulates the synaptonemal complex to ensure chromosome pairing during female meiosis

Project description:Sexual reproduction relies on meiotic recombination and the accurate segregation of homologous chromosomes to generate viable, genetically diverse gametes. While the molecular mechanisms of recombination and chromosome segregation are well studied, the upstream regulatory cues that drive expression of key meiotic genes remain poorly understood, especially in metazoans. Emerging evidence suggests that post-transcriptional regulation plays a central role in initiating and coordinating the meiotic program in both fruit flies and mammals. Here, we identify the RNA-binding protein Ataxin-2 (Atx2) as a crucial regulator of meiosis in Drosophila melanogaster. We show that Atx2 positively regulates critical meiotic factors, especially components of the synaptonemal complex (SC), a structure essential for pairing, recombination and segregation of homologous chromosomes. In Atx2-depleted germ cells, SC component mRNA and protein levels are markedly reduced, leading to defective SC assembly and maintenance. Consequently, homologous chromosomes fail to pair properly, which is essential to ensure homolog segregation and prevent aneuploidy. These findings uncover Atx2 as a key regulator of the SC and highlight an underappreciated layer of gene regulation essential for accurate meiotic chromosome segregation and fertility.

2026-02-27 | GSE318364 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data