Project description:Staphylococcus borealis sp.nov., a novel member of the Staphylococcaceae family isolated from skin and blood in humans
| PRJEB38160 | ENA
Project description:Genome assembly of Fusarium cerealis (syn. crookwellense), member of Fusarium sambucinum species complex, isolated from New Zealand pasture
Project description:Tapasin is a member of the peptide loading complex which is responsible for stabilizing empty HLA molecules and facilitating the loading of antigenic peptides. Many neuroblastoma cell lines contain low baseline levels of HLA due to defects in antigen processing and presentation machinery. Supplementing the neuroblastoma cell line EBc1 with tapasin-TM, an altered form of tapasin containing the transmembrane domain of HLA-G, enhances surface HLA expression. Here, we have applied our previously used deep mutational scanning library (GSE159247) to the tapasin-TM construct. We then introduced this library into EBc1 cells and isolated cells with the highest surface HLA-A2 expression.
Project description:Related surrogate species are often used to study the molecular basis of pathogenicity of a pathogen on the basis of a shared set of biological features generally attributable to a shared core genome consisting of orthologous genes. An important and understudied aspect, however, is the extent to which regulatory features affecting the expression of such shared genes are present in both species. Here we report on an analysis of whole transcriptome maps for an important member of the TB complex Mycobacterium bovis and a closely related model organism for studying mycobacterial pathogenicity Mycobacterium marinum. Predict transcription start site
Project description:Related surrogate species are often used to study the molecular basis of pathogenicity of a pathogen on the basis of a shared set of biological features generally attributable to a shared core genome consisting of orthologous genes. An important and understudied aspect, however, is the extent to which regulatory features affecting the expression of such shared genes are present in both species. Here we report on an analysis of whole transcriptome maps for an important member of the TB complex Mycobacterium bovis and a closely related model organism for studying mycobacterial pathogenicity Mycobacterium marinum.
