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Molecular Epidemiology of Multi- and Extensively-Drug-Resistant Mycobacterium tuberculosis in Ireland, 2001-2014

ABSTRACT: Molecular Epidemiology of Multi- and Extensively-Drug-Resistant Mycobacterium tuberculosis in Ireland, 2001-2014

PROVIDER: PRJEB15076 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR1952140_1.fastq.gz	Fastqsanger.gz
	ERR1952140_2.fastq.gz	Fastqsanger.gz
	ERR1952141_1.fastq.gz	Fastqsanger.gz
	ERR1952141_2.fastq.gz	Fastqsanger.gz
	ERR1952142_1.fastq.gz	Fastqsanger.gz

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Project description:BackgroundInfluenza B is characterised by two antigenic lineages: B/Victoria and B/Yamagata. These lineages circulate together with influenza A during influenza seasons, with varying incidence from year to year and by geographic region.ObjectiveTo determine the epidemiology of influenza B relative to influenza A in Australia.MethodsLaboratory-confirmed influenza notifications between 2001 and 2014 in Australia were obtained from the Australian National Notifiable Diseases Surveillance System.ResultsA total of 278 485 laboratory-confirmed influenza cases were notified during the study period, comprising influenza A (82.2%), B (17.1%) and 'other and untyped' (0.7%). The proportion of notifications that were influenza B was highest in five- to nine-year-olds (27.5%) and lowest in persons aged 85 years and over (11.5%). Of all B notifications with lineage determined, 77.1% were B/Victoria and 22.9% were B/Yamagata infections. Mismatches between the dominant B lineage in a season and the trivalent vaccine B lineage occurred in over one-third of seasons during the study years. In general, influenza B notifications peaked later than influenza A notifications.ConclusionThe proportion of circulating influenza B in Australia during 2001-2014 was slightly lower than the global average and was dominated by B/Victoria. Compared with influenza A, influenza B infection was more common among older children and young adults and less common in the very elderly. Influenza B lineage mismatch with the trivalent vaccine occurred about one-third of the time.

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