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Transcriptional profiling of Setd5 heterozygous and knockout mouse embryonic stem cells

ABSTRACT: Transcriptional profiling of Setd5 heterozygous and knockout mouse embryonic stem cells

PROVIDER: PRJEB16759 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR1710153_1.fastq.gz	Fastqsanger.gz
	ERR1710153_2.fastq.gz	Fastqsanger.gz
	ERR1710154_1.fastq.gz	Fastqsanger.gz
	ERR1710154_2.fastq.gz	Fastqsanger.gz
	ERR1710155_1.fastq.gz	Fastqsanger.gz

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Transcriptional profiling of Setd5 heterozygous and knockout mouse embryonic stem cells

Project description:SET-domain containing proteins play a vital role in regulating gene expression during development through modifications in chromatin structure. To study molecular function of SET domain containing 5 (Setd5), we assessed global changes in the mouse embryonic stem cell transcriptome when Setd5 gene is knocked out.

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SETD5 is a H3K36 methyltransferase which preserves transcriptional fidelity during brain development and neuronal wiring [ChIP-seq]

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Project description:We assess the role of Setd5 on trancription elongation, by profiling nascent chromatin bound RNAs after DRB treatment an release, in wild type and Setd5 heterozygous mouse neural stem cells (NSCs).

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Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice [bulk RNA]

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