Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

PGP-UK

ABSTRACT: Personal Genome Project - United Kingdom

PROVIDER: PRJEB17529 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERS1176551_noHLA.vcf.gz	Vcf
	ERS1176551_noHLA.vcf.gz.tbi	Vcf
	ERS1176552_noHLA.vcf.gz	Vcf
	ERS1176552_noHLA.vcf.gz.tbi	Vcf
	ERS1176553_noHLA.vcf.gz	Vcf

Items per page:

1 - 5 of 284

Similar Datasets

GNPS - 370 UK Pseudomonas

Project description:Extracts from 370 Pseudomonas fluorescens isolates from wheat from the United Kingdom.

2016-03-31 | MSV000079619 | GNPS

RNA-seq data from the pilot study of the 'Personal Genome Project UK': PGP-UK10

Project description:This study consists of 10 whole genome RNA-seq profiles which have been generated from blood samples collected from ten different volunteers in the Personal Genome Project UK

2018-03-04 | E-MTAB-6523 | biostudies-arrayexpress

HumanMethylation450 data from the pilot study of the 'Personal Genome Project UK': PGP-UK10 and the first three genome donations

Project description:This study consists of 24 genome-wide methylation profiles which have been generated from blood and saliva samples collected from ten volunteers in the Personal Genome Project UK. The Personal Genome Project UK aims to create publicly available genome, health and trait data, and these ten volunteers represent the pilot study (PGP-UK10) and the first three genome donation participants. These samples were bisulphite converted using the EZ DNA methylation kit (Zymo), using the alternative incubation conditions recommended for HumanMethylation450 BeadChip (Illumina). Genome-wide DNA methylation was then profiled using the HumanMethylation450 BeadChip (Illumina).

2016-12-12 | E-MTAB-5377 | biostudies-arrayexpress

Avastin (Bevacizumab) in the Treatment of Metastatic Colorectal Cancer in Normal Clinical Use in the UK Population

Project description:This study will focus on participants in the United Kingdom (UK) to collect local data on the effectiveness and safety of bevacizumab (Avastin) in the treatment of metastatic colorectal cancer in normal clinical use.

| 2197544 | ecrin-mdr-crc

Comparative gene expression profiling of human PGP1 iPS, lymphocyte, donor fibroblasts

Project description:Human iPS cell line, immortalized B-cells, and primary fibroblasts frome Personal Genome Project voluteer 1

2014-03-04 | GSE54733 | GEO

Homo sapiens

Project description:Personal Genome Project

| PRJNA294706 | ENA

Homo sapiens

Project description:Personal Genome Project

| PRJNA294707 | ENA

UK M. pneumoniae isolated

Project description:Comparative genomic analysis of Mycoplasma pneumoniae isolated in the United Kingdom, between 2016-2024

| PRJEB84194 | ENA

Transcription profiling of human primary gastric cancer expression profiles (UK Patient Cohort)

Project description:Genome-wide mRNA expression profiles of 31 primary gastric tumors from the UK patient cohort. Gastric cancer (GC) is the second leading cause of global cancer mortality, with individual gastric tumors displaying significant heterogeneity in their deregulation of various oncogenic pathways. We aim to identify major oncogenic pathways in GC that robustly impact patient survival and treatment response. We used an in silico strategy based on gene expression signatures and connectivity analytics to map patterns of oncogenic pathway activation in 25 unique GC cell lines, and in 301 primary gastric cancers from three independent patient cohorts. Of 11 oncogenic pathways previously implicated in GC, we identified three predominant pathways (proliferation/stem cell, NF-kB, and Wnt/b-catenin) deregulated in the majority (>70%) of gastric tumors. Using a variety of proliferative, Wnt, and NF-kB-related assays, we experimentally validated the pathway predictions in multiple GC cell lines showing similar pathway activation patterns in vitro. Patients stratified at the level of individual pathways did not exhibit consistent differences in clinical outcome. However, patients grouped by oncogenic pathway combinations demonstrated robust and significant survival differences (e.g., high proliferation/high NF-kB vs. low proliferation/low NF-kB), suggesting that tumor behavior in GC is likely influenced by the combined effects of multiple oncogenic pathways. Our results demonstrate that GCs can be successfully taxonomized by oncogenic pathway activity into biologically and clinically relevant subgroups. Experiment Overall Design: Profiling of 31 primary gastric tumors on Affymetrix GeneChip Human Genome U133 Array Set HG-U133A. All tumors were collected with approvals from the St James's University Hospital, United Kingdom and the Research Ethics Review Committee.

2009-04-10 | E-GEOD-15456 | biostudies-arrayexpress

Project description:Polish personal genome project

| PRJNA639768 | ENA