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Stone-age-plague-2017

ABSTRACT: The Stone Age Plague: 1000 years of Persistence in Eurasia

PROVIDER: PRJEB19335 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR2112550_1.fastq.gz	Fastqsanger.gz
	ERR2112550_2.fastq.gz	Fastqsanger.gz
	ERR2112560_1.fastq.gz	Fastqsanger.gz
	ERR2112560_2.fastq.gz	Fastqsanger.gz
	ERR2112570.fastq.gz	Fastqsanger.gz

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Polarization profiling of renal macrophages in stone model mice

Project description:We recently reported elimination of renal crystals and migration of macrophages (MM-OM-^F) around crystals in hyperoxaluric mice, suggesting MM-OM-^Fs might eliminate crystals. MM-OM-^Fs are of 2 phenotypes: inflammatory (M1) and anti-inflammatory (M2). Because M2MM-OM-^Fs are considered to be involved in tissue repair and regeneration, we focused attention on their suppressive role in renal crystal formation. Hence, we investigated the gene array profiling of renal macrophages in stone model mice and CSF-1-deficient stone model mice. B6C3Fe a/a-Csf1op/J wild type/homozygous mice were admistered 80mg/kg gyyoxylate (GOX) for 6days, then the kidneys were extracted and sorted CD11b+/CD11c+ macrophages using autoMACS. The gene expression of WT- and op/op-macrophages were investigated using bone marrow derived M1/M2 macrophages as controls.

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Kidney Stone Induces Developmental Stage-specific Alterations in Gene Expression

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