SIR
Ontology highlight
ABSTRACT:
PROVIDER: PRJEB23970 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| ERR2222860.fastq.gz | Fastqsanger.gz | |||
| ERR2222860_1.fastq.gz | Fastqsanger.gz | |||
| ERR2222860_2.fastq.gz | Fastqsanger.gz | |||
| ERR2222870.fastq.gz | Fastqsanger.gz | |||
| ERR2222870_1.fastq.gz | Fastqsanger.gz |
Items per page: 5 1 - 5 of 228 |
Similar Datasets
Project description:The objective of this study was to investigate the impact of genotypic variation on both early microbial colonization of the gut and functional development of intestinal tissue. From two genetically diverse chicken lines intestinal content samples were taken for microbiota analyzes and intestinal tissue samples were extracted for gene expression analyzes, both at three subsequent time-points (days 0, 4, and 16).
2016-01-14 | GSE65042 | GEO
Project description:Impact of iron, GOS and LF on Kenyan infant gut microbiota in vitro
| PRJEB63476 | ENA
Project description:Understanding the interfacial structure between nanomaterials and lipoproteins is crucial for gaining profound insights into how nanomaterials impact lipoprotein structure and interfere with lipid metabolism. In this study, we employed graphene oxide (GO) nanosheets (NSs) with precisely controlled surface hydrophilicity as model nanomaterials to investigate the influence of surface properties on lipoprotein corona formation. Our findings reveal that hydrophobic GOs exhibit a greater affinity for binding with low-density lipoprotein (LDL). To explore the interaction between GOs and LDL at the interface, we employed advanced techniques such as X-ray reflectivity, circular dichroism, and molecular simulation. Specifically, hydrophobic GOs showed a preference for associating with the lipid components of LDL, while hydrophilic ones tended to bind with apolipoproteins. Furthermore, our research demonstrated that these GOs distinctly modulate various lipid metabolism pathways, including LDL recognition, uptake, hydrolysis, efflux, and lipid droplet formation. This comprehensive investigation underscores the significance of structural analysis at the nano-biomolecule interface and emphasizes the critical role of nanomaterial’s surface properties in mediating cellular lipid metabolism. Our findings carry profound implications and can serve as a source of inspiration for the future design of biocompatible nanomaterials and nanomedicines.
2025-05-06 | PXD044475 | Pride
Project description:Impact of Nutritional Interventions on Chicken Gut Microbiome
| PRJEB81427 | ENA
Project description:Short-chain fatty acids (SCFAs) are the end-products of bacterial fermentation of dietary fibre, and can play a crucial role in regulating immunity and metabolism in the gut and peripheral tissues. Here we show that butyrrate, an SCFA, displayed antiviral effects in chicken respiratory epithelial cells, likely via the regulation of interferon-stimulated genes, particularly OASL. The observed antiviral signaling mechanism would involve HDAC inhibition and Sp1-dependent regulation of the OASL promoter, shedding light on new mechanisms through which the GM regulates poultry mucosal immunity along the gut-lung axis in the chicken.
2024-08-28 | E-MTAB-14346 | biostudies-arrayexpress
Project description:Bacteroidaceae are common gut microbiota members in all warm-blooded animals. However, if Bacteroidaceae are to be used as probiotics, the species selected for different hosts should reflect the natural distribution. In this study, we therefore evaluated host adaptation of bacterial species belonging to the family Bacteroidaceae. B. dorei, B. uniformis, B. xylanisolvens, B. ovatus, B. clarus, B. thetaiotaomicron and B. vulgatus represented human-adapted species while B. gallinaceum, B. caecigallinarum, B. mediterraneensis, B. caecicola, M. massiliensis, B. plebeius and B. coprocola were commonly detected in chicken but not human gut microbiota. There were 29 genes which were present in all human-adapted Bacteroides but absent from the genomes of all chicken isolates and these included genes required for the pentose cycle, and glutamate or histidine metabolism. These genes were expressed during an in vitro competitive assay, in which human-adapted Bacteroides species overgrew the chicken adapted isolates. Not a single gene specific for the chicken-adapted species was found. Instead, chicken adapted species exhibited signs of frequent horizontal gene transfer, of KUP, linA and sugE genes in particular. The differences in host adaptation should be considered when the new generation of probiotics for humans or chickens is designed.
2020-09-28 | PXD020954 | Pride
Project description:The gut of chicken is mostly colonised with Campylobacter jejuni and with 100 fold less C. coli. The competitive ability of C. coli OR12 over C. jejuni OR1 has been examined in experimental broiler chickens following the observation that C. coli replaced an established C. jejuni intestinal colonisation within commercial chicken flocks reared outdoors (El-Shibiny, A., Connerton, P.L., Connerton, I.F., 2005. Enumeration and diversity of campylobacters and bacteriophages isolated during the rearing cycles of free-range and organic chickens. Applied Environmental Microbiology. 71, 1259-1266).
2015-09-15 | GSE17805 | GEO
Project description:Campylobacter jejuni is the major cause of acute gastroenteritis in the developed world. It is usually acquired through contaminated poultry as C. jejuni causes a silent asymptomatic infection of the chicken. Pathogens face different sources of stress during its transit through the gut. In this study, we describe the ability of C. jejuni to survive nitrosative stress at very low oxygen levels that reflect those in hypoxic gut environments. Specifically, we here explore an innovative model of signal recognition during colonization. We use a diffusion capsule to feed small, diffusible molecules from chicken caecal matter into a microaerobic C. jejuni culture to study the transcriptomic changes mounted as response to chemical signals present in the chicken gut. We find that in early stages of exposure to the caecal contents (10 min) the dual component colonization regulator, dccR, plays an important yet not fully understood role. Although the caecal material contains cyanide derived from plant sources, we find no role for a truncated globin (encoded by ctb), which has previously been implicated in resistance to this haem ligand.
2012-08-07 | GSE39917 | GEO