Ontology highlight
ABSTRACT:
PROVIDER: PRJEB25855 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Molecular composition of serum exosomes
2023-06-21 | E-PROT-109 | ExpressionAtlas
Project description:Simple Markov model for a disease model.
The model uses two disease states: Alive and Dead, where the Dead state terminates simulation.
The yearly probability of transition between states Alive and Dead is: 0.05
Initial conditions: 100 people start in Alive and none in Dead.
Output: Number of people in each state for years 1-10.
2019-01-30 | MODEL1803120002 | BioModels
Project description:RNA-seq of 17 breast tumor samples of three different subtypes and normal human breast organoids samples
2025-01-24 | E-GEOD-52194 | ExpressionAtlas
Project description:Microarray was performed on PBMC with an inflammatory dedicated slide of 340 genes, and target samples labelled with Cy3 for day 0 (reference) and with Cy5 for the other days. Changes in expression levels were evaluated by the ratio Dx/D0. According to outcome and time evolution, a two-dimensional clustering was performed. Keywords: dead vs alive septic shock patients at D1 post-inclusion
2006-08-01 | GSE5262 | GEO
Project description:RNA-Seq of Schistosoma mansoni (flatworms) larva and adult individuals at different life-stages
2019-05-15 | E-MTAB-451 | ExpressionAtlas
Project description:Transcription profiling by array of human liposarcoma samples with different histological subtypes
2025-01-24 | E-GEOD-20559 | ExpressionAtlas
Project description:Rationale: Serial measurements of genome-wide transcriptional changes in alveolar macrophages (AMs) in patients with acute respiratory distress syndrome (ARDS) could identify dynamic biologic processes that are associated with clinical outcomes. Objectives: To identify associations between AM transcriptional programs and the composite endpoint of ventilator-free days (VFDs) over the course of ARDS. Methods: We performed unbiased genome-wide transcriptional profiling of AMs purified from bronchoalveolar lavage fluid collected from patients with ARDS. Cells were obtained at baseline (Day 1), Day 4, and Day 8 after ARDS onset. We assessed pathway enrichment in subjects with VFDs > 0 (VFD-Extubated/Alive) versus VFDs = 0 (VFD-Intubated/Dead) at each time point. Measurements and Main Results: We found highly divergent AM transcriptional patterns at all time points between ARDS patients based on their VFD status (FDR < 0.05). “M1-like” and pro-inflammatory gene sets such as IL-6-JAK-STAT signaling were significantly enriched in AMs isolated on Day 1 in VFD-Extubated/Alive versus VFD-Intubated/Dead subjects. In contrast, many of these same gene sets were associated with the VFD-Intubated/Dead subjects on Day 8. In patients who had samples from each time point, we identified multiple AM gene clusters whose temporal expression patterns were associated with VFD status. The relationship between AM expression profiles and VFDs was distinct in subjects with Direct (pulmonary) versus Indirect (extrapulmonary) ARDS. Conclusion: Clinically meaningful outcomes over the course of ARDS are associated with highly distinct AM transcriptional programs. Our findings suggest that interventions targeting the alveolar immune response should be tested within strictly defined time periods.
2019-03-31 | GSE116560 | GEO
Project description:In the present study we evaluated the miRNA expression profile of 31 high risk, stage 4 neuroblastoma patients. We compared miRNA expression profiles of 14 long-survivors (alive with an overall survival time > 36 months) and 17 short-survivors (dead of disease within 36 months from diagnosis. Deaths due to toxicity were censored).
2010-05-16 | E-GEOD-16444 | biostudies-arrayexpress
Project description:Human Body Index - Transcription profiling by array of human samples with various different diseases
2025-01-24 | E-GEOD-7307 | ExpressionAtlas