Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparative genome sequence analysis of the globally disseminated Escherichia coli ST131 lineage

ABSTRACT: Comparative genome sequence analysis of the globally disseminated Escherichia coli ST131 lineage

PROVIDER: PRJEB2968 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR161234_1.fastq.gz	Fastqsanger.gz
	ERR161234_2.fastq.gz	Fastqsanger.gz
	ERR161235_1.fastq.gz	Fastqsanger.gz
	ERR161235_2.fastq.gz	Fastqsanger.gz
	ERR161236_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 192

Similar Datasets

Lineage-Specific Methyltransferases Define the Methylome of the Globally Disseminated Escherichia coli ST131 Clone.

Project description: Not available

| S-EPMC4659465 | biostudies-literature

Escherichia coli O25b:H4-ST131 strain:EC958

Project description:The serum resistome of the globally disseminated, multidrug resistant uropathogenic E. coli ST131 strain EC958

| PRJNA189704 | ENA

Insights into a multidrug resistant Escherichia coli pathogen of the globally disseminated ST131 lineage: genome analysis and virulence mechanisms.

Project description: Not available

| S-EPMC3203889 | biostudies-literature

Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131 E. coli to Carbapenem Exposure

Project description:Background: It remains unclear how high-risk Escherichia coli lineages, like sequence type (ST) 131, initially adapt to carbapenem exposure in its progression to becoming carbapenem resistant. Methods: Carbapenem mutation frequency was measured in multiple subclades of extended-spectrum β-lactamase (ESBL) positive ST131 clinical isolates using a fluctuation assay followed by whole genome sequencing (WGS) characterization. Genomic, transcriptomic, and porin analyses of ST131 C2/H30Rx isolate, MB1860, under prolonged, increasing carbapenem exposure was performed using two distinct experimental evolutionary platforms to measure fast vs. slow adaptation. Results: All thirteen ESBL positive ST131 strains selected from a diverse (n=184) ST131 bacteremia cohort had detectable ertapenem (ETP) mutational frequencies with a statistically positive correlation between initial ESBL gene copy number and mutation frequency (r = 0.87, P<1e-5). WGS analysis of mutants showed initial response to ETP exposure resulted in significant increases in ESBL gene copy numbers or mutations in outer membrane porin (Omp) encoding genes in the absence of ESBL gene amplification with subclade specific adaptations. In both experimental evolutionary platforms, MB1860 responded to initial ETP exposure by increasing blaCTX-M-15 copy numbers via modular, insertion sequence 26 (IS26) mediated pseudocompound transposons (PCTns). Transposase activity driven by PCTn upregulation was a conserved expression signal in both experimental evolutionary platforms. Stable mutations in Omp encoding genes were detected only after prolonged increasing carbapenem exposure consistent with clinical observations. Conclusions: ESBL gene amplification is a conserved response to initial carbapenem exposure, especially within the high-risk ST131 C2 subclade. Targeting such amplification could assist with mitigating carbapenem resistance development.

2024-08-04 | GSE273456 | GEO

The complete genome sequence of Escherichia coli EC958: a high quality reference sequence for the globally disseminated multidrug resistant E. coli O25b:H4-ST131 clone.

Project description: Not available

| S-EPMC4134206 | biostudies-literature

Pathogenicity Islands in Uropathogenic <i>Escherichia coli</i> Clinical Isolate of the Globally Disseminated O25:H4-ST131 Pandemic Clonal Lineage: First Report from Egypt.

Project description: Not available

| S-EPMC9686529 | biostudies-literature

Molecular characterization of a multidrug resistance IncF plasmid from the globally disseminated Escherichia coli ST131 clone.

Project description: Not available

| S-EPMC4398462 | biostudies-literature

E coli ST131 lineage C1/H30R blaCTX-M-27

Project description:Emergence of blaCTX-M-27-encoding Escherichia coli ST131 lineage C1/H30R clone in clinical isolates in Germany.

| PRJEB21697 | ENA

Gene expression of disseminated neuroblastoma

Project description:Comprehensive expression profiling of disseminated neuroblastoma with favorable and unfavorable outcome using SAGE. Results provide insight into the molecular pathogenesis of spontaneous regression and progression of metastatic neuroblastoma and may be used for improving risk estimation of patients with disseminated neuroblastoma. Keywords: gene expression SAGE-based, neuroblastoma, primary tumor, disseminated disease Samples analyzed: 9 (stage 4S neuroblastoma: n=5, stage 4 neuroblastoma: n=3, neuroblastoma cell line: n=1)

2006-09-06 | E-GEOD-4991 | biostudies-arrayexpress

Gene expression of disseminated neuroblastoma

2006-09-06 | GSE4991 | GEO