Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

VRE hospital epidemiology Germany

ABSTRACT: Whole genome sequencing of 773 VREfm patient samples

PROVIDER: PRJEB30772 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR3053630_1.fastq.gz	Fastqsanger.gz
	ERR3053630_2.fastq.gz	Fastqsanger.gz
	ERR3053640_1.fastq.gz	Fastqsanger.gz
	ERR3053640_2.fastq.gz	Fastqsanger.gz
	ERR3053650_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 1546

Similar Datasets

VRE hospital epidemiology Germany

Project description:Whole genome sequencing of 773 VREfm patient samples

| PRJEB30783 | ENA

Vancomycin-resistant enterococci (VRE) in hospital settings across European borders: a scoping review comparing the epidemiology in the Netherlands and Germany.

Project description: Not available

| S-EPMC10422769 | biostudies-literature

VRE ST1421 in Tasmania

Project description:Draft genome sequence of a new sequence type, ST1421, of Vancomycin-Resistant Enterococcus faecium (VREfm)

| PRJEB25735 | ENA

The potential of genome-oriented blood culture surveillance of vancomycin-resistant enterococcus faecium (VRE) to mirror local VRE epidemiology: a retrospective analysis and systematic comparison of VRE blood culture and VRE first patient isolates.

Project description: Not available

| S-EPMC12670834 | biostudies-literature

Project description:Whole genome sequencing of VREfm from Suzhou

| PRJNA717634 | ENA

SARS-CoV-2 positive hospital staff and patients

Project description:Sequencing SARS-CoV-2 positive hospital staff and patient samples

| PRJEB43319 | ENA

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium

Project description:Vancomycin-resistant Enterococcus faecium (VREfm) is a leading cause of healthcare-associated infections globally and demands new approaches for treatment. Here we show that genetic and pharmacological inactivation of a highly conserved NlpC/P60 peptidoglycan hydrolase, secreted antigen A (SagA), enhanced vancomycin susceptibility of VREfm ex vivo and in vivo. Notably, genetic deletion of sagA impaired VREfm peptidoglycan remodeling, growth and increased the activity of vancomycin. We then identified first-in-class covalent NlpC/P60 peptidoglycan hydrolase inhibitors and demonstrated that pharmacological inactivation of SagA activity also impaired peptidoglycan remodeling and increased the efficacy of vancomycin in several VREfm clinical isolates. Our study reveals peptidoglycan hydrolases are druggable targets whose inactivation improves the efficacy of vancomycin against VREfm.

2026-04-13 | PXD075040 | Pride

Saliva cell type DNA methylation reference panel for epidemiology studies in children

Project description:We profiled the DNA methylation of saliva cell types, to develop a tool for epidemiologic studies. Saliva was collected from 22 children, 21 participants with samples usable for DNA methylation, and sorted into immune and epithelial cells, using size exclusion filtration and magnetic bead sorting. DNA methylation was measured using the Illumina MethylationEPIC BeadChip. Saliva immune and epithelial cells have distinct DNA methylation profiles, which can influence whole saliva epidemiologic measures.

2020-09-01 | GSE147318 | GEO

Human Rhinoviruses in Pediatric Patients in a Tertiary Care Hospital in Germany: Molecular Epidemiology and Clinical Significance.

Project description: Not available

| S-EPMC9415293 | biostudies-literature

Human Rhinoviruses in Adult Patients in a Tertiary Care Hospital in Germany: Molecular Epidemiology and Clinical Significance.

Project description: Not available

| S-EPMC8539166 | biostudies-literature