Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell transcriptional profiling of induced reprogramming trajectories

ABSTRACT: Single-cell transcriptional profiling of induced reprogramming trajectories

PROVIDER: PRJEB32940 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR3363920.fastq.gz	Fastqsanger.gz
	ERR3363930.fastq.gz	Fastqsanger.gz
	ERR3363940.fastq.gz	Fastqsanger.gz
	ERR3363950.fastq.gz	Fastqsanger.gz
	ERR3363960.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 1009

Similar Datasets

Transcriptional profiling of induced reprogramming trajectories

Project description:Transcriptional profiling of induced reprogramming trajectories

| PRJEB32971 | ENA

Single-cell transcriptional profiling of induced reprogramming trajectories

Project description:To elucidate the interplay between signal transduction and transcriptional regulation in cellular reprogramming, distinct induction routes from epiblast stem cells to naïve pluripotency were evaluated and compared.

2019-08-16 | E-MTAB-7901 | biostudies-arrayexpress

Transcriptional profiling of induced reprogramming trajectories

2019-08-16 | E-MTAB-8046 | biostudies-arrayexpress

Aligning single-cell developmental and reprogramming trajectories identifies molecular determinants of reprogramming outcome

Project description:Aligning single-cell developmental and reprogramming trajectories identifies molecular determinants of reprogramming outcome

| PRJNA415061 | ENA

Transcriptional trajectories of human kidney injury progression

Project description:Transcriptional trajectories of human kidney injury progression

| PRJNA523370 | ENA

Transcriptional profiling of chemical Dot1L inhibition during reprogramming to induced pluripotent stem cells

Project description:Transcriptional profiling of chemical Dot1L inhibition during reprogramming to induced pluripotent stem cells

| PRJNA673631 | ENA

Etv2-induced MEF reprogramming

Project description:Etv2-induced MEF reprogramming

| PRJNA770380 | ENA

SUMOylation controls the rapid transcriptional reprogramming induced by chemotherapies in Acute Myeloid Leukemias

Project description:Genotoxicants have been used for decades as front-line therapies against cancer on the basis of their DNA-damaging actions. However, some of their non-DNA-damaging effects are also instrumental for killing dividing cells. We report here that the anthracycline Daunorubicin (DNR), one of the main drugs used to treat Acute Myeloid Leukemia (AML), induces broad transcriptional changes in AML cells before cell death induction. The regulated genes are particularly enriched in genes controlling cell proliferation and death, as well as inflammation and immunity. These transcriptional changes are preceded by DNR-dependent deSUMOylation of chromatin proteins, which limits both the positive and negative effects of DNR on transcription. Quantitative proteomics shows that proteins that are deSUMOylated in response to DNR are mostly transcription factors, transcriptional co-regulators and chromatin organizers. Among them, the CCCTC-binding factor CTCF is highly enriched at SUMO-binding sites found in cis-regulatory regions. This is notably the case at the promoter of the DNR-induced NFKB2 gene. Its induction is preceded by a SUMO-dependent reconfiguration of chromatin loops engaging its CTCF- and SUMO-bound promoter with distal cis-regulatory regions. Altogether, our work suggests that one of the earliest effects of DNR in AML cells is a SUMO-dependent transcriptional reprogramming.

2023-06-23 | PXD032956 | Pride

The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming

Project description:The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming

| PRJNA612855 | ENA

Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming

Project description:Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming

| PRJNA505909 | ENA