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RNA sequencing in islets from Rip-Cre CDK8fl/fl and CDK8fl/fl mice with or without metabolic stress.

ABSTRACT: RNA sequencing in islets from Rip-Cre CDK8fl/fl and CDK8fl/fl mice with or without metabolic stress.

PROVIDER: PRJEB33747 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR3456320.fastq.gz	Fastqsanger.gz
	ERR3456321.fastq.gz	Fastqsanger.gz
	ERR3456322.fastq.gz	Fastqsanger.gz
	ERR3456323.fastq.gz	Fastqsanger.gz
	ERR3456324.fastq.gz	Fastqsanger.gz

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RNA sequencing in islets from Rip-Cre CDK8fl/fl and CDK8fl/fl mice with or without metabolic stress.

Project description:mRNA of pancreatic islets from Rip-Cre CDK8fl/fl and CDK8fl/fl mice were sequenced to investigate the consequence of genetic CDK8 ablation on genome wide transcript levels. Additionally, Rip-Cre CDK8fl/fl and CDK8fl/fl mice were stressed with STZ and then islets from those mice were sequenced to describe the transcriptome-wide regulation of beta-cells under stress condition.

2019-08-30 | E-MTAB-8201 | biostudies-arrayexpress

Expression data from pancreatic islets from Men1flf RIP-Cre mice, Rbp2flf RIP-Cre mice, Men1flf Rbp2flf RIP-Cre mice and matched control.

Project description:The menin tumor suppressor protein (Men1) is deficient in many endocrine tumors and forms an active complex with MLL family histone methyltransferases. This Men1 complex promotes histone H3 lysine 4 trimethylation at target loci including homeobox genes and cyclin-dependent kinase inhibitor genes. The loss of Men1 may be tumorigenic because it leads to decreased histone H3 lysine 4 trimethylation resulting in expressional changes of specific genes. Reversing tumorigenesis induced by a Men1 deficiency might be achieved by inhibition of histone H3 lysine 4 demethylase Rbp2 (Kdm5a). To this end, pancreatic islets from Men1f|f, Rbp2f|f and Men1f|f Rbp2f|f mice were expression profiled to determine what transcriptional changes induced by a Men1 deficiency are reversed by the loss of Rpb2. Pancreatic islets were isolated from Men1flf RIP-Cre mice, Rbp2flf RIP-Cre mice, Men1flf Rbp2flf RIP-Cre mice and two month old matched control mice. Total mRNA was extracted from islets and expression profiled on microarrays.

2011-07-25 | E-GEOD-26978 | biostudies-arrayexpress

Single-cell gene expression profiles of pancreatic islets from two β-cell specific knockout mouse models (βZKO-Mip and βZKO-Rip), along with RIP-Cre and MIP-Cre mice, were analyzed after being fed a high-fat diet (HFD).

Project description:The islet is composed of diverse cell types that work together to regulate its endocrine function. To investigate this, we performed comparative single-cell RNA sequencing (scRNA-seq) on islets from 16-week-old βZKO-Mip, βZKO-Rip, RIP-Cre, and MIP-Cre mice, all of which were fed a high-fat diet (HFD) from 12 to 16 weeks. Sequencing was carried out using the Chromium Next GEM Single Cell 3' Reagent Kits. Each islet sample was derived from at least three mice with the same genotype.

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Twist2-Cre liver vs Twist2-Cre/A20fl/fl liver in mice

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Atp4b-Cre;Cdh1(fl/fl);Kras(LSL-G12D/+);Trp53(fl/fl);Rosa26(LSL-YFP/LSL-YFP) mouse stomach vs. Atp4b-Cre;Cdh1(fl/+);Kras(LSL-G12D/+);Trp53(fl/fl);Rosa26(LSL-YFP/LSL-YFP) mouse stomach microarray

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2018-05-01 | E-MTAB-5833 | biostudies-arrayexpress

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RNA-seq analysis of Mettl3fl/fl and LysM-cre, Mettl3fl/fl MDSC Transcriptomes

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