Project description:Tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases in an individual, we analyzed multiple tumors from men with disseminated prostate cancer through whole-exome sequencing, array comparative genomic hybridization (CGH) and RNA transcript profiling, and we compared the genomic diversity within and between individuals.

2016-02-16 | GSE77930 | GEO

Alectoria sarmentosa strain:MAF-Lich 21536 | isolate:MAF-Lich 21536

Project description:Alectoria sarmentosa strain:MAF-Lich 21536 | isolate:MAF-Lich 21536 Genome sequencing and assembly

| PRJNA588068 | ENA

Cryptic diversity in Cytherissa ostracods

Project description:Cryptic diversity and speciation in endemic Cytherissa (Ostracoda, Crustacea) from Lake Baikal

| PRJEB21475 | ENA

Differences in Genetic Diversity of Tick-Borne Flaviviruses

Project description:There are very few studies exploring the genetic diversity of tick-borne encephalitis complex viruses. Most of the viruses have been sequenced using capillary electrophoresis, however, very few viruses have been analyzed using deep sequencing to look at the genotypes in each virus population. In this study, different viruses and strains belonging to the tick-borne encephalitis complex were sequenced and genetic diversity was analyzed. Shannon entropy and single nucleotide variants were used to compare the viruses. Then genetic diversity was compared to the phylogenetic relationship of the viruses.

2023-12-04 | E-MTAB-12112 | biostudies-arrayexpress

Cryptic diversity in Nearctic Lasius ants

Project description:Integrative taxonomy reveals cryptic diversity in North American Lasius ants, and an overlooked introduced species

| PRJEB49643 | ENA

Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity

Project description:ZIKV strains belong to three phylogenetic lineages: East African, West African, and Asian/American. RNA virus genomes exist as populations of genetically-related sequences whose heterogeneity may impact viral fitness, evolution, and virulence. The genetic diversity of representative ZIKVs (N=7) from each lineage was examined using next generation sequencing (NGS) paired with downstream Shannon entropy calculation and single nucleotide variant (SNV) analysis. This comprehensive analysis of ZIKV genetic diversity provides insight into the genetic diversity of ZKIV and repository of SNV positions across lineages.

2019-07-30 | E-MTAB-7771 | biostudies-arrayexpress

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