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RNA seq of MLL-ENL transformed cells under serine/glycine starvation including a starvation resistant clone

ABSTRACT: RNA seq of MLL-ENL transformed cells under serine/glycine starvation including a starvation resistant clone

PROVIDER: PRJEB36459 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR3843140.fastq.gz	Fastqsanger.gz
	ERR3843141.fastq.gz	Fastqsanger.gz
	ERR3843142.fastq.gz	Fastqsanger.gz

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RNA seq of MLL-ENL transformed cells under serine/glycine starvation including a starvation resistant clone

Project description:Primary hematopoietic cells were transformed by retrovirally transduced MLL-ENL. The resulting cell population was either cultured in full medium or under starvation conditions without serine and glycine. In addition a spontaneously arising ser/gly starvation resistant clone was included in this experiment. Nascent RNA was isolated by labeling cells for 1h with 4-thio-uridine and subsequent biotinylation of labeled RNA followed by streptavidin chromatography as described in Garcia-Cuellar et al. CellReports S22111247(16)30259-5.

2021-06-21 | E-MTAB-8738 | biostudies-arrayexpress

The next-generation RNA and ATAC sequencing of MLL-ENL transformed cell lines reveals that C/EBP transcription factors coordinate the expression of the MLL-ENL/Hoxa target genes [ATAC-seq]

Project description:We report the application of next-generation RNA and ATAC sequencing technology for high-throughput profiling of MLL-ENL transformed cell lines. According to our results, the C/EBP transcription factors coordinate the expression of the MLL-ENL/Hoxa target genes. Genetic removal of both Cebpa and Cebpb revealed a surrogate function of C/EBPε for myeloid MLL-ENL transformation.

2020-10-30 | GSE153623 | GEO

The next-generation RNA and ATAC sequencing of MLL-ENL transformed cell lines reveals that C/EBP transcription factors coordinate the expression of the MLL-ENL/Hoxa target genes [RNA-seq]

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RNA-Seq of human AML samples, and human cells transformed with MLL-ENL or MLL-AF6

Project description:RNA-Seq of 1) human AML samples; 2) sorted, uncultured distinct population from human cord blood (CB); 3) short-term (ST) cultured sorted CB cells transduced with MLL-ENL, MLL-AF6 or untransduced; and 4) cultured (LT) sorted CB cells transformed with MLL-ENL or MLL-AF6. Cells from MLL-fusion AML patients are bulk. Several cords were used for the sorting (CB1, CB2, CB3, 135, 141...) and these represent biological replicates. Several samples were sequenced several times in different lanes and results were merged together for the analysis (rep1,rep2...). Samples were used to determine the different effect of MLL-fusions in different celltypes just after the transduction, and after a longer time period when cells were transformed. Sorted CB samples, uncultured as well as transformed by MLL-fusions, were used in machine learning approach to predict which of the patients originated from which cell-type of origin.

2021-01-31 | E-MTAB-5501 | biostudies-arrayexpress

Transcriptome changes following acute serine starvation in breast cancer cells

Project description:Transcriptome changes following acute serine starvation in breast cancer cells

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Epigenomic changes following acute serine starvation in breast cancer cells

Project description:Epigenomic changes following acute serine starvation in breast cancer cells

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Transcriptomic and epigenomic changes following acute serine starvation in breast cancer cells

Project description:Transcriptomic and epigenomic changes following acute serine starvation in breast cancer cells

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Transcriptomic profiling of MLL-ENL and delta YEATS mutant

Project description:To investigate the contribution of ENL YEATS domain and downstream sequences in MLL-ENL leukemogenesis program, we generated MLL-ENL and MLL-ENL ∆YEATS (ENL aa372-559) cell lines by retrovirally introducing these constructs into lineage negative hematopoietic stem and progenitor cells (HSPCs).

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RNA-Seq of human AML samples, and human cells transformed with MLL-ENL or MLL-AF6

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ChIP-seq of CD117-positive primary hematopoietic precursor cell from Meer mice that carry a leukemogenic knock-in of an inducible ENL-ER portion into the mouse Mll locus

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