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Gene expression analysis of 83A25-stimulated EL4 cells

ABSTRACT: Gene expression analysis of 83A25-stimulated EL4 cells

PROVIDER: PRJEB36787 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR3928910_1.fastq.gz	Fastqsanger.gz
	ERR3928910_2.fastq.gz	Fastqsanger.gz
	ERR3928920_1.fastq.gz	Fastqsanger.gz
	ERR3928920_2.fastq.gz	Fastqsanger.gz
	ERR3928911_1.fastq.gz	Fastqsanger.gz

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Project description:c-Rel and RelA are members of the NF-kappaB family of transcription factors. They both have important roles in T cell activation. To discover where in the genome c-Rel and RelA bind and hence which genes they may directly target, we used ChIP-chip with EL4 cells stimulated with phorbol ester (PMA) and Ionomycin. We have identified regions in EL4 cells (background strain: C57BL/6N) activated for 2h or 8h by PMA and Ionomycin, that bind the transcription factors c-Rel and RelA. Immunoprecipitated samples from EL4 cells stimulated with PMA and ionomycin for 2 h and 8 h with antibodies against RelA or c-Rel respectively were used for ChIP-on-chip experiments. In addition, samples from total input and mock immunoprecipitation were used as controls. Biological triplicates were used.

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