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Modulation of the zebrafish (Danio rerio) larval microbiota

ABSTRACT: Modulation of the zebrafish (Danio rerio) larval microbiota by potential probiotic yeasts

PROVIDER: PRJEB38908 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR4250140_1.fastq.gz	Fastqsanger.gz
	ERR4250140_2.fastq.gz	Fastqsanger.gz
	ERR4250150_1.fastq.gz	Fastqsanger.gz
	ERR4250150_2.fastq.gz	Fastqsanger.gz
	ERR4250160_1.fastq.gz	Fastqsanger.gz

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Mechanism suppressing transcription of the globin genes in Danio rerio nonerythroid cells

Project description:In genomes of modern fish and amphibia α- and β- globin genes are grouped at a single locus that may resemble the ancestral one and is syntenic to α-globin locus of modern warm-blooded vertebrates. In Danio rerio, the major locus of α/β globin genes comprises two subclusters, one of them harboring genes expressed in adult and the other – genes expressed in embryonic and larval erythrocytes. The results of our previous study suggested that the adult subcluster of this locus has evolved into α-globin gene domain of vertebrate animals. Here we studied how adult and embryo-larval genes of Danio rerio major globin gene locus are repressed in fibroblasts. The results obtained suggest that that at least some of the globin genes present within the adult subcluster are repressed by Polycomb similarly to human α-globin genes. Furthermore, within two α/β gene pairs repression of α-type and β-type genes appears to be mediated by different mechanisms as increasing the level of histone acetylation can activate transcription of only β-type genes.

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