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Naturally prevailing microorganisms in zinc and copper minerals processing

ABSTRACT: Naturally prevailing microorganisms in zinc and copper minerals processing

PROVIDER: PRJEB41552 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR4901890.fastq.gz	Fastqsanger.gz
	ERR4901900.fastq.gz	Fastqsanger.gz
	ERR4901910.fastq.gz	Fastqsanger.gz
	ERR4901920.fastq.gz	Fastqsanger.gz
	ERR4901930.fastq.gz	Fastqsanger.gz

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Project description:In this study we used a transcriptomic approach to study the molecular determinants of the synergy between copper and fluconazole, in Candida glabrata, the second most frequent cause of invasive candidiasis. We demonstrate that copper acts together with fluconazole by downregulating three distinct pathways: azole efflux, ergosterol biosynthesis and zinc homeostasis. Coincidently, all these pathways are important for C. glabrata to cope with fluconazole stress. Therefore, when copper and fluconazole are combined cells fail to detoxify this drug and accumulate toxic methylated intermediates of sterol metabolism. This accumulation, possibly together with copper-induced lipid damages, should affect the activity of plasma membrane transporters, which impedes zinc uptake, leading to zinc depletion

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