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Cut&Run-seq of MUTZ3 cells to investigate changes in a translocated enhancer following CRISPR treatment

ABSTRACT: Cut&Run-seq of MUTZ3 cells to investigate changes in a translocated enhancer following CRISPR treatment

PROVIDER: PRJEB42209 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	ERR5019970_1.fastq.gz	Fastqsanger.gz
	ERR5019970_2.fastq.gz	Fastqsanger.gz
	ERR5019971_1.fastq.gz	Fastqsanger.gz
	ERR5019971_2.fastq.gz	Fastqsanger.gz
	ERR5019972_1.fastq.gz	Fastqsanger.gz

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Cut&Run-seq of MUTZ3 cells to investigate changes in a translocated enhancer following CRISPR treatment

Project description:We examined the effects of targeting the GATA2 super-enhancer on EVI1 expression in MUTZ3. To that end, we conducted genome editing with CRISPR and assessed H3K27 acetylation with Cut&Run. The protocol described by the Henikoff group was used to generate these data.

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ATAC-seq of MUTZ3 cells in experiments to investigate EVI1 regulation

Project description:Open chromatin regions were analyzed by ATAC-seq in MUTZ3 and MOLM1 cell lines (both inv(3) AML) to characterize the GATA2 super-enhancer region. ATAC-seq was performed as described (Buenrostro et al., 2013) with a modification in the lysis buffer to reduce mitochondrial DNA contamination.

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Analysis of chromatin occupancy in erythroid cells by CUT&RUN following CRISPR editing of BCL11A enhancer

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ChIP-seq of MUTZ3 cells in experiments to investigate EVI1 regulation by CRISPR or compound treatment

Project description:ChIP-seq of MUTZ3 cells in experiments to investigate EVI1 regulation by CRISPR or compound treatment

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Project description:We profiled medullary thymic epithelial cells by CUT&RUN to investigate mechanisms of T-cell tolerance.

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ChIP-seq of MUTZ3 cells in experiments to investigate EVI1 regulation by CRISPR or compound treatment

Project description:ChIP-seq was conducted to evaluate the effect of deleting a MYB binding site in the GATA2 super-enhancer or treating MUTZ3 cells with a MYB inhibitor. H3K27ac, MYB and p300 ChIP-seq datasets were generated.

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