Project description:10-12 day old liquid MS grown Arabidopsis seedlings were either treated with JA-Ile or control for 30 min. Three biological replicates of treated and control were then subjected to RNA isolation and a gene expression analysis was done.

2022-07-13 | E-MTAB-11508 | biostudies-arrayexpress

Transcriptome of Escherichia coli cells in coculture (Ile auxotroph and Leu auxotroph)

Project description:We conducted experimental evolution of E. coli a mutual cross-feeding coculture, composed of two genetically-engineered Escherichia coli populations, I- and L-, which lack genes for biosynthesis of Ile (ilvE gene) and Leu (leuB gene), respectively. These two populations grew in a coculture by complementing required nutrients each other. After 883 generations of evolution experiments, we measured evolutionary changes in transcriptome, and we found ABC transporters for the branched chain amino acids (Ile, Leu, and Val) were significantly increased in both I- and L-. Also, we got other various results that would be interesting to discuss.

2017-07-15 | GSE101471 | GEO

Methylome of Lotus japonicus accession 'Gifu'

Project description:Whole genome DNA methylation data for the the Lotus japonicus accession 'Gifu'

2016-12-01 | GSE73069 | GEO

arabidopsis accession columbia 78h old whole seedling expression

Project description:four biological replicates of arabidopsis accession columbia 78h old whole seedling expression data Keywords: exon/intergenic comparison

2006-12-19 | GSE6562 | GEO

Foraminifera cDNA

Project description:Foraminifera cDNA Raw sequence reads

| PRJNA783139 | ENA

A Pilot Study for Protective Roles of tRNA-Derived Small RNA tRF-Ile-AAT-019 in Pathological Progression of Psoriasis

Project description:Psoriasis is a chronic recurrent inflammatory skin disease that is characterized by abnormal proliferation and differentiation of keratinocytes (KCs), angiogenesis and skin inflammation. tRNA-derived small RNA (tsRNA), including tRNA halves and tRNA fragments (tRFs), is a novel class of short non-coding RNA, possessing regulatory functions in many diseases. However, its role in the pathological development of psoriasis has been unknown. In this pilot study, we conducted small RNA sequencing to screen differentially expressed tRFs in psoriatic skin lesions as compared with normal controls. We found 130 upregulated and 104 downregulated tRFs, among which downregulation of tRF-Ile-AAT-019 in psoriatic skin lesions was further confirmed. Bioinformatics analysis by TargetScan and Miranda algorithms revealed that tRF-Ile-AAT-019 might target SERPINE1, thus regulating HIF-1α signaling pathway. We next showed that increased tRF-Ile-AAT-019 could downregulate expressions of SERPINE1, HIF-1α and vascular proliferative markers such as CD34, CD31, Factor VIII, and VEGF, but upregulate expressions of KCs differentiation markers including Keratin1 and Involucrin. Our data suggest that tRF-Ile-AAT-019 plays a protective role in the pathological progression of psoriasis via targeting SERPINE1 and blocking HIF-1α signaling pathway, leading to control KCs differentiation and vascular proliferation. This data provides a potential novel targeting pathway for the disease treatment.

2021-02-19 | GSE167057 | GEO

DNA microarray analysis using duodenum from wild-type or IAP knockout (Akp3-/-) mice administered with IIAEK (Ile-Ile-Ala-Glu-Lys)

Project description:DNA microarray analysis using duodenum from wild-type or IAP knockout (Akp3-/-) mice administered with IIAEK (Ile-Ile-Ala-Glu-Lys)

| PRJNA1230066 | ENA

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