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ChIP-seq analyses of Hap4 and Hap5 genome-wide binding patterns in the pathogenic yeast Candida glabrata

ABSTRACT: ChIP-seq analyses of Hap4 and Hap5 genome-wide binding patterns in the pathogenic yeast Candida glabrata

PROVIDER: PRJEB45943 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR6131800.fastq.gz	Fastqsanger.gz
	ERR6131810.fastq.gz	Fastqsanger.gz
	ERR6131801.fastq.gz	Fastqsanger.gz
	ERR6131811.fastq.gz	Fastqsanger.gz
	ERR6131802.fastq.gz	Fastqsanger.gz

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Transcriptional analyses to decipher iron homeostasis in the pathogenic yeast Candida glabrata.

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ChIP-seq analyses of Hap4 and Hap5 genome-wide binding patterns in the pathogenic yeast Candida glabrata

Project description:We analyzed the DNA binding pattern of the Hap5 and Hap4 transcription factors by ChIP-seq in Candida glabrata. Myc-tagged versions of the two transcription factors were used. The mock IP was performed with an untagged, otherwise isogenic, strain. IP and Input DNA were sequenced on a Nextseq illumina machine. All cells were grown in rich media containing glycerol as the sole carbon source. Peak calling was performed using the bpeaks software, with the input and the IP used as references.

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Limosilactobacillus fermentum Limits Candida glabrata Growth by Ergosterol Depletion

Project description:Candida glabrata is a human-associated opportunistic fungal pathogen. It shares its niche with Lactobacillus spp. in the gastrointestinal and vaginal tract. In fact, Lactobacillus species are thought to competitively prevent Candida overgrowth. We investigated the molecular aspects of this antifungal effect by analyzing the interaction of C. glabrata strains with Limosilactobacillus fermentum. From a collection of clinical C. glabrata isolates, we identified strains with different sensitivities to L. fermentum in coculture. We analyzed the variation of their expression pattern to isolate the specific response to L. fermentum. C. glabrata-L. fermentum coculture induced genes associated with ergosterol biosynthesis, weak acid stress, and drug/chemical stress. L. fermentum coculture depleted C. glabrata ergosterol. The reduction of ergosterol was dependent on the Lactobacillus species, even in coculture with different Candida species. We found a similar ergosterol-depleting effect with other lactobacillus strains (Lactobacillus crispatus and Lactobacillus rhamosus) on Candida albicans, Candida tropicalis, and Candida krusei. The addition of ergosterol improved C. glabrata growth in the coculture. Blocking ergosterol synthesis with fluconazole increased the susceptibility against L. fermentum, which was again mitigated by the addition of ergosterol. In accordance, a C. glabrata Derg11 mutant, defective in ergosterol biosynthesis, was highly sensitive to L. fermentum. In conclusion, our analysis indicates an unexpected direct function of ergosterol for C. glabrata proliferation in coculture with L. fermentum.

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