Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Colistin-resistant Escherichia coli from retail meat in Southern Italy

PROVIDER: PRJEB47231 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR6575632_1.fastq.gz	Fastqsanger.gz
	ERR6575632_2.fastq.gz	Fastqsanger.gz
	ERR6575633_1.fastq.gz	Fastqsanger.gz
	ERR6575633_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Project description:Colistin-resistant Escherichia coli

| PRJNA1274168 | ENA

CTX-M-65-producing E. coli

Project description:CTX-M-65 in multidrug resistant Escherichia coli from retail meat

| PRJEB42244 | ENA

RNAseq transcriptome analysis of K. pneumoniae MS6671 and E. coli MS8345 treated with PBT2

Project description:The emergence of colistin resistance in carbapenem-resistant and extended-spectrum ß-lactamase (ESBL)-producing bacteria is a significant threat to human health, and new treatment strategies are urgently required. Here we investigated the ability of the safe-for-human use ionophore PBT2 to restore antibiotic sensitivity in several polymyxin-resistant, ESBL-producing, carbapenem resistant Gram-negative human pathogens. PBT2 was observed to resensitize Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa to last-resort polymyxin class antibiotics, including a ‘next generation’ polymyxin derivative, FADDI-287. To gain additional insight into the potential mechanism of action of PBT2, we analyzed the transcriptome of K. pneumoniae and E. coli in the presence of sub-inhibitory concentrations of PBT2. Treatment with PBT2 was associated with multiple stress responses in both K. pneumoniae and E. coli. Significant changes in the transcription of transition metal ion homeostasis genes were observed in both strains.

2019-06-13 | GSE132637 | GEO

TraDIS-Xpress finds mechanisms of action and synergies of a novel lipid IVA biosynthesis inhibitor

Project description:We used TraDIS-Xpress to determine the mechanism of action of a novel antimicrobial compound. We found that it inhibits lipid IVA biosynthesis in both Escherichia coli and Salmonella enterica serovar Typhimurium. We also were able to determine mechanisms of synergy with colistin, through ATP biosynthesis and the BasSR signalling system.

2023-08-31 | E-MTAB-13250 | biostudies-arrayexpress

RNAseq by using Illumina Hiseq (RNA library was generated using TruSeq RNA library prep kit)

Project description:Acinetobacter baumannii is often highly resistant to multiple antimicrobials, posing a risk of treatment failure. Colistin is often chosen as a “last resort” for treatment of the bacterial infection, but resistance is easily developed when the bacteria is exposed to the drug. Thus a comprehensive analysis of colistin-mediated changes in colistin-susceptible and colistin-resistant A. baumannii is needed. In this study, we used a colistin-susceptible A. baumannii clinical isolate and a colistin-resistant isogenic mutant. Whole genome sequencing revealed that the resistant isolate harbored a PmrBL208F mutation conferring colistin resistance, and all other single nucleotide alterations were located in intergenic regions. Using scanning electron microscopy, we observed that the colistin-resistant mutant had a shorter cell length than the parental isolate, and filamented cells were observed when both isolates were exposed to inhibitory concentration of colistin. When the isolates were treated with inhibitory concentrations of colistin, more than 80% of the genes were upregulated, including genes associated with antioxidative stress response pathways. This results helped a better understanding for the morphological difference between the colistin-susceptible and –resistant isolates and differed colistin-mediated responses in A. baumannii isolates by their susceptibility to this drug.

2025-05-02 | GSE267612 | GEO

Escherichia coli

Project description:Colistin resistant Escherichia coli from commercial pig farms

| PRJNA928227 | ENA

Project description:Colistin resistant E. coli

| PRJNA731849 | ENA

Escherichia coli

Project description:Colistin resistant E. coli

| PRJNA735516 | ENA

Project description:Conjugative Transmission of carbapenem-resistant and colistin-resistant hypervirulent Escherichia coli

| PRJNA1005813 | ENA

Project description:WGS of pathogenic colistin-resistant Escherichia coli from cattle