Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Acquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells

ABSTRACT: Acquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells

PROVIDER: PRJEB50831 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Acquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells

Project description:Acquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells

| PRJNA739554 | ENA

Acquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells

Project description:Our data show that Wnt and FGF signalling, and the downstream transcription factors NKX2.1 and TFAP2C, promote human alveolar or airway fate respectively. Moreover, we have functionally validated cell-cell interactions in human lung alveolar patterning. We show that Wnt signalling from differentiating fibroblasts promotes alveolar type 2 cell identity, whereas myofibroblasts secrete the Wnt inhibitor, NOTUM, providing spatial patterning. Our organoid system recapitulates key aspects of human lung development allowing mechanistic experiments to determine the underpinning molecular regulation.

2022-02-28 | E-MTAB-11435 | biostudies-arrayexpress

Contribution of molecular actors from somatic origin to oocyte developmental competence acquisition, lessons from evolution

Project description:This SuperSeries is composed of the following subset Series: GSE36602: Transcriptional profiling of somatic cells differentiation throughout oocyte competence acquisition in rainbow trout ovarian follicles. GSE36603: Transcriptional profiling of somatic cells differentiation throughout oocyte competence acquisition in the xenopus ovarian follicles. GSE36604: Transcriptional profiling of cumulus cells differentiation throughout oocyte competence acquisition in the murine ovarian follicles. GSE36605: Transcriptional profiling of cumulus cells differentiation throughout oocyte competence acquisition in the bovine ovarian follicles. Refer to individual Series

2012-10-14 | E-GEOD-36617 | biostudies-arrayexpress

Transcriptional Reprogramming during Floral Fate Acquisition

Project description:Transcriptional Reprogramming during Floral Fate Acquisition

| PRJNA844340 | ENA

Geminin represses mesendoderm cell fate acquisition in embryoid bodies

Project description:Geminin is a small nucleoprotein that neuralizes ectoderm in the Xenopus embryo. Geminin promotes neural fate acquisition of mouse embryonic stem cells: Geminin knockdown during neural fate acquisition decreased expression of neural precursor cell markers (Pax6, Sox1), while increasing expression of Pitx2, Lefty1 and Cited2, genes involved in formation of the mouse node. Here we differentiated mouse embryonic stem cells into embryoid bodies to study Geminin's ability to repress primitive streak mesendoderm fate acquisition. We used microarrays to define the sets of genes that are regulated by Geminin during cell fate acquisition in embryoid bodies, using Dox-inducible Geminin knockdown or overexpression mouse embryonic stem cell lines. ES cell lines for Geminin over-expression (GemOE) were treated without or with Dox from day 3 to day 5 of EB differentiation and were collected on days 4 or 5 for microarray analysis. Gem knockdown (KD) ES cell lines were treated without or with Dox from day 0 to day 4 of EB differentiation and were collected on day 4 for microarray analysis.

2014-07-01 | E-GEOD-39676 | biostudies-arrayexpress

Cumulus cell gene expression associated with pre-ovulatory acquisition of developmental competence in bovine oocytes

Project description:This study investigated the cumulus cell (CC) transcriptomic changes during the oocyte developmental competence acquisition period.

2016-04-01 | GSE79760 | GEO

Acquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-30 | GSE178529 | GEO

Transcriptional Reprogramming during Floral Fate Acquisition I

Project description:Transcriptional Reprogramming during Floral Fate Acquisition I

| PRJNA844352 | ENA

Transcriptional Reprogramming during Floral Fate Acquisition III

Project description:Transcriptional Reprogramming during Floral Fate Acquisition III

| PRJNA844349 | ENA

Transcriptional Reprogramming during Floral Fate Acquisition II

Project description:Transcriptional Reprogramming during Floral Fate Acquisition II