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Microbial inoculation of yedoma permafrost incubations, Vault permafrost tunnel, Alaska

ABSTRACT: Vault permafrost tunnel, Alaska, inoculation study

PROVIDER: PRJEB51405 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR9118880_1.fastq.gz	Fastqsanger.gz
	ERR9118880_2.fastq.gz	Fastqsanger.gz
	ERR9118890_1.fastq.gz	Fastqsanger.gz
	ERR9118890_2.fastq.gz	Fastqsanger.gz
	ERR9118881_1.fastq.gz	Fastqsanger.gz

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Exploring the vault interactome in the divergent eukaryote Trypanosoma brucei

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NSun2-mediated cytosine-5 methylation in Vault non-coding RNA determines its processing into small RNAs [iCLIP]

Project description:Autosomal-recessive loss of the NSUN2 gene has been recently identified as a causative link to intellectual disability disorders in humans. NSun2 is an RNA methyltransferase modifying cytosine-5 in transfer RNAs (tRNA). Whether NSun2 methylates additional RNA species is currently debated. Here, we adapted the individual-nucleotide resolution UV cross-linking and immunoprecipitation method (iCLIP) to identify NSun2-mediated methylation in RNA transcriptome. We confirm site-specific methylation in tRNA and identify messenger and non-coding RNAs as potential methylation targets for NSun2. Using RNA bisulfite sequencing we establish Vault non-coding RNAs as novel substrates for NSun2 and identified six cytosine-5 methylated sites. Furthermore, we show that loss of cytosine-5 methylation in Vault RNAs causes aberrant processing into argonaute-associating small RNA fragments (svRNA). Thus, impaired Vault non-coding RNA processing may be an important contributor to the etiology of NSUN2-deficieny human disorders.

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NSun2-mediated cytosine-5 methylation in Vault non-coding RNA determines its processing into small RNAs [iCLIP]

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NSun2-mediated cytosine-5 methylation in Vault non-coding RNA determines its processing into small RNAs [RNA-seq]

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NSun2-mediated cytosine-5 methylation in Vault non-coding RNA determines its processing into small RNAs [RNA-seq]

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