Project description:The vertebrate inner ear arises from a pool of progenitors with the potential to give rise to all the sense organs and cranial ganglia of the head1-6. Here we explore the molecular mechanisms that control ear specification from these progenitors. Using a multi-omics approach combined with loss-of-function experiments we identify a core transcriptional circuit that imparts ear identity, along with non-coding elements that integrate this information. This analysis places the transcription factor Sox8 at the top of the ear determination network. Introducing Sox8 into cranial ectoderm not only converts non-ear cells into ear progenitors, but also activates the cellular programmes for ear morphogenesis and neurogenesis. Thus, Sox8 emerges as a master regulator of ear identity and may be a key factor for sense organ cell reprogramming.

2022-07-06 | GSE168083 | GEO

Sox8 reprograms ectoderm into ear vesicles and associated neurons [ATAC-seq]

2022-07-06 | GSE168082 | GEO

Canceled by the investigator. Observation and study on ear image specific changes and auricular points electrical characteristics in patients with intestinal polyps

Project description:Interventions: Case group:Record of ear acupoints bioelectrical measurements and acupoint image-specificity observation and annotation were performed;Control group:Record of ear acupoints bioelectrical measurements and acupoint image-specificity observation and annotation were performed Primary outcome(s): ear acupoints bioelectrical measurements Study Design: Factorial

| 82321 | ecrin-mdr-crc

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data