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Genetic changes of sotorasib-resistant cells

ABSTRACT: Genetic changes of sotorasib-resistant cells

PROVIDER: PRJEB55843 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR10162504_1.fastq.gz	Fastqsanger.gz
	ERR10162504_2.fastq.gz	Fastqsanger.gz
	ERR10162505_1.fastq.gz	Fastqsanger.gz
	ERR10162505_2.fastq.gz	Fastqsanger.gz
	ERR10162506_1.fastq.gz	Fastqsanger.gz

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Genetic changes of sotorasib-resistant cells

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Acute and Long-Term/Resistant Gene Expression Changes in H23 Cells Due to Sotorasib Treatment

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Project description:To investigate the transcriptinal alterations in Sotorasib sensitive and cells acquired resistance to Sotorasib. The Sotorasib resistant cell lines of H358 and LU65 were generated following chronic treatment with Sotorasib. We then performed gene expression profiling analysis using data obtained from RNA-seq of parental and resistant lines.

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Acute and Long-Term/Resistant Gene Expression Changes in H23 Cells Due to Sotorasib Treatment

Project description:Acute and Long-Term/Resistant Gene Expression Changes in H23 Cells Due to Sotorasib Treatment

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Development of acquired resistance to sotorasib in NCI-H358 cell line in vitro

Project description:NCI-H358 is a KRAS G12C-mutant non-small lung cancer cell line known to be sensitive to KRAS G12C-inhibitor sotorasib. Here, we aimed to develop sotorasib resistance in H358 and interrogate the resulting sotorasib-resistant cell line (H358-R). The H358-R cell line was created by continuous culturing of the H358 cells in sotorasib (250 nM) until cells grew readily under sotorasib pressure (approximately 2 months). We then performed RNA-seq of the resulting sotorasib-resistant cell line (H358-R) with and without sotorasib pressure, compared to the parental sensitive cell line control (H358). KRAS gene expression level was found to be increased in the sotorasib-resistant line compared with the parental cells, likely representing a mechanism of resistance. The increased KRAS expression level in the resistant cell line was maintained under sotorasib pressure.

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