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Genome-wide identification and DNA methylation of human full-length LINE-1 (L1) retrotransposons in HCT116 cells treated with 5-aza-2’-deoxycytidine.

ABSTRACT: Genome-wide identification and DNA methylation of human full-length LINE-1 (L1) retrotransposons in HCT116 cells treated with 5-aza-2’-deoxycytidine.

PROVIDER: PRJEB56470 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR10308506_1.fastq.gz	Fastqsanger.gz
	ERR10308506_2.fastq.gz	Fastqsanger.gz
	ERR10308507_1.fastq.gz	Fastqsanger.gz
	ERR10308507_2.fastq.gz	Fastqsanger.gz
	ERR10308508_1.fastq.gz	Fastqsanger.gz

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Genome-wide identification and DNA methylation of human full-length LINE-1 (L1) retrotransposons in HCT116 cells treated with 5-aza-2’-deoxycytidine.

Project description:We used bs-ATLAS-seq to comprehensively map the genomic location and assess the DNA methylation status of human full-length LINE-1 elements (L1). The approach is focused on the youngest family (L1HS), but it also catches a significant fraction of L1PA2 to L1PA8 elements. This was performed in HCT116 cells treated by the DNA methyltransferase inhibitor 5-aza-2’-deoxycytidine (5-aza) or in mock-treated cells (DMSO).

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