Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of novel and already known altered micoRNAs lead to a deeper understanding of the development of type 1 diabetes mellitus

ABSTRACT: Identification of novel and already known altered micoRNAs lead to a deeper understanding of the development of type 1 diabetes mellitus

PROVIDER: PRJEB59759 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR10862800.fastq.gz	Fastqsanger.gz
	ERR10862801.fastq.gz	Fastqsanger.gz
	ERR10862802.fastq.gz	Fastqsanger.gz
	ERR10862803.fastq.gz	Fastqsanger.gz
	ERR10862804.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 30

Similar Datasets

Identification of novel and already known altered micoRNAs lead to a deeper understanding of the development of type 1 diabetes mellitus

Project description:Type 1 diabetes is a chronic autoimmune disease which results in inefficient regulation of glucose homeostasis and can lead to different vascular comorbidities through life. Next generation sequencing analysis was firstly performed to identify miRNAs that were differentially expressed between groups (20 patients vs. 10 controls). The aim of this study is to analyze the expression profile of circulating miRNAs in the plasma of adult patients with well-established type 1 diabetes and with no associated comorbidities, compared to healthy subjects, to identify miRNAs that are specific from diabetes pathology, and to assess pathways and biological processes related to the state of this disease.

2024-01-01 | E-MTAB-12641 | biostudies-arrayexpress

undefined

Project description:Identification of novel and already known altered micoRNAs would lead to a deeper understanding of the development of type 1 diabetes mellitus.

| PRJEB59117 | ENA

Understanding the role of Type 1 diabetes mellitus in osteoarthritis

Project description:Type 1 diabetes mellitus (T1DM) affects 9.5% of the population. T1DM is characterized by severe insulin deficiency that causes hyperglycemia and leads to several systemic effects. T1DM has been suggested as a risk factor for articular cartilage damage and loss, which could expedite the development of osteoarthritis (OA). OA represents a major public health challenge by affecting 300 million people globally, yet very little is known about the correlation between T1DM and OA. In this study we aimed to understand the role of T1DM in OA by evaluating whether pre-existing T1DM exacerbates the development of knee post traumatic osteoarthritis (PTOA). Here we describe the transcriptomic differences between the knee joints of STZ injected C57BL/6J mice (T1DM) and control mice

2022-03-17 | GSE198836 | GEO

Proteomics of <i>Penicillium chrysogenum</i> for a Deeper Understanding of Lead (Pb) Metal Bioremediation.

Project description:Penicillium chrysogenum (P. chrysogenum), a ubiquitous filamentous fungus, has demonstrated remarkable potential in the bioremediation of lead-contaminated environments. Its inherent tolerance and bioaccumulation capacity for lead (Pb), coupled with its relatively rapid growth rate, make it an attractive candidate for bioremediation applications. This study aims to identify the proteomic changes in P. chrysogenuminduced by Pb metal stress and unravel the roles of identified proteins in molecular mechanisms and cellular responses. Untargeted proteomic analysis was carried out using a two-dimensional difference in gel electrophoresis (2D-DIGE) coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). This study reported the identification of 43 statistically significant proteins (24 upregulated and 19 downregulated, ANOVA, p ≤ 0.05; fold change ≥1.5) in P. chrysogenum as a consequence of Pb treatment. Proteins were grouped according to their function into 18 groups from which 13 proteins were related to metabolism, 11 were related to cellular process and signaling, and 19 proteins were related to information storage and processing. The current study is considered the first report about the proteomics study of P. chrysogenum under Pb stress conditions, where upregulated proteins could better explain the mechanism of tolerance and Pb toxicity removal. Our research has provided a thorough understanding of the molecular and cellular processes involved in fungal-metal interactions, paving the way for the development of innovative molecular markers for heavy metal myco-remediation. To the best of our knowledge, this study of P. chrysogenum provides valuable insights toward growing research in comprehending the metal-microbe interactions. This will facilitate development of novel molecular markers for metal bioremediation.

| S-EPMC11190926 | biostudies-literature

Understanding the role of Type 1 diabetes mellitus in osteoarthritis

Project description:Understanding the role of Type 1 diabetes mellitus in osteoarthritis

| PRJNA817158 | ENA

Lead-seq: transcriptome-wide in vivo structure probing with lead

Project description:Lead-seq: transcriptome-wide in vivo structure probing with lead

| PRJNA590387 | ENA

Type 2 Diabetes mellitus: mRNA and miRNA profiling

Project description:This SuperSeries is composed of the following subset Series: GSE21321: Blood microRNA profiles and upregulation of hsa-miR-144 in males with type 2 diabetes mellitus. GSE26167: MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in Type 2 Diabetes mellitus Refer to individual Series

2010-12-18 | E-GEOD-26168 | biostudies-arrayexpress

Urinary bladder disease in rat experimental diabetes mellitus

Project description:Diabetes mellitus (DM) is a leading cause of chronic kidney disease and the pathobiology of diabetic nephropathy is widely studied. Less, however, is known about urinary bladder disease in DM despite dysfunctional voiding being a common clinical problem. We hypothesised that diabetic cystopathy would have a characteristic molecular signature, due to the adaptive response to increased urine load combined with the metabolic impacts of DM. To distinguish the consequences of DM from polyuria we compared bladders of untreated control, diabetic (streptozotocin-induced) and sucrose-treated male Wistar rats after 16 weeks using gene array

2021-07-17 | E-MTAB-9255 | biostudies-arrayexpress

Diabetes Mellitus Type 1 miRnome

Project description:Diabetes Mellitus Type 1 miRnome

| PRJEB51173 | ENA

Homo sapiens isolate:not known

Project description:Homo sapiens isolate:not known Genome sequencing

| PRJNA449839 | ENA