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Transcriptome analysis of Candida auris response to tunicamycin

ABSTRACT: Transcriptome analysis of Candida auris response to tunicamycin

PROVIDER: PRJEB60034 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR10905079_1.fastq.gz	Fastqsanger.gz
	ERR10905079_2.fastq.gz	Fastqsanger.gz
	ERR10905080_1.fastq.gz	Fastqsanger.gz
	ERR10905080_2.fastq.gz	Fastqsanger.gz
	ERR10905081_1.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of Candida auris response to tunicamycin

Project description:Candida auris reference strain B11221 was exposed to sub-inhibitory (1μg/ml) and inhibitory (8μg/ml) tunicamycin for 3h. Transcriptomes were compared to no drug treatment control.

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Candida auris derived tunicamycin adaptors using high amount of tunicamcyin

Project description:Candida auris reference strain B11221 was spread on YPD plate supplemented with 8 μg/ml tunicamycin. Randomly 25 adaptors (T2080-T2104) were chosen. These adaptors and the parent were sequenced.

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Whole genome sequencing of tunicamycin adaptors in Candida auris

Project description:Candida auris clade III isolate B11221 was spread on YPD plate supplemented with 8 µg/ml tunicamycin. Randomly 18 adaptors were chosen for further analysis. We did sequencing of these 18 adaptors as well as the parent.

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Whole genome sequencing of tunicamycin (8 µg/ml) adaptors in Candida auris

Project description:Candida auris clade III isolate B12039 was spread on YPD plate supplemented with 8 µg/ml tunicamycin. Randomly 27 adaptors were chosen for further analysis. We did sequencing of these 27 adaptors as well as the parent.

2021-06-13 | E-MTAB-10549 | biostudies-arrayexpress

Whole genome sequencing of tunicamycin (4 µg/ml) adaptors in Candida auris

Project description:Candida auris clade III isolate B12039 was spread on YPD plate supplemented with 4 µg/ml tunicamycin. Randomly 27 adaptors were chosen for further analysis. We did sequencing of these 27 adaptors as well as the parent.

2021-06-24 | E-MTAB-10626 | biostudies-arrayexpress

Whole genome sequencing of tunicamycin adaptors in Candida auris

Project description:Whole genome sequencing of tunicamycin adaptors in Candida auris

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Transcriptome analysis of tebuconazole adaptors in Candida auris

Project description:Candida auris wild type strain FY279 was used to tebuconazole adaptors. Transcriptomes of two adaptors, TJ42 and TJ44, were compared to wild type.

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Candida auris derived tunicamycin adaptors using high amount of tunicamcyin

Project description:Candida auris derived tunicamycin adaptors using high amount of tunicamcyin

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Haploid and Deploid for Candida auris

Project description:The expression difference for haploid and deploid of Candida auris

2020-09-13 | GSE149284 | GEO

Candida auris-macrophage cellular interactions and transcriptional response

Project description:The pathogenic yeast Candida auris represents a global threat of the utmost clinical relevance. This emerging fungal species is remarkable in its resistance to commonly used antifungal and its persistence in the nosocomial settings. The innate immune system is one the first lines of defense preventing the dissemination of pathogens in the host. C. auris is susceptible to circulating phagocytes, namely neutrophils. However, some gaps of knowledge remain regarding the cellular and transcriptional responses towards other phagocytic lineages. In this work, we examined the interactions of this yeast with macrophages. We found that macrophages avidly phagocytose C. auris, however intracellular replication is not inhibited, indicating that C. auris is able to resist the killing mechanisms imposed by the phagocyte. Intracellular replication does not induce macrophage lysis, however. The transcriptional response of C. auris to macrophage phagocytosis is very similar to other members of the CUG clade (C. albicans, C. tropicalis, C. parapsilosis, C. lusitaniae), i.e., downregulation of transcription/translation and upregulation of alternative carbon metabolism pathways, transporters and induction of oxidative stress response and proteolysis. Gene family expansions are common in this yeast, and we found that many of these genes are induced in response to macrophage co-incubation. Among these, amino acid and oligopeptide transporters, as well as lipases and proteases are upregulated. Thus, C. auris shares key transcriptional signatures shared with other fungal pathogens and capitalizes on the expansion of gene families coding for potential virulence attributes that allow its survival, persistence, and evasion of the innate immune system.

2024-06-28 | GSE236004 | GEO

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