Project description:Human gingival epithelial cells (HGEp) and fibroblasts (HGF) are the main cell types of the peri-implant soft-tissue, with HGEp constantly being exposed to bacteria and HGF residing protected in the connective tissue as long as an intact mucosa-implant seal is preserved. Streptococcus oralis belongs to the commensal bacteria, is highly abundant at healthy implant sites, and might exert host modulatory effects on soft-tissue cells as described for other streptococci. Thus, we aimed to investigate the effects of S. oralis biofilm on HGEp as well as HGF. HGEp or HGF were grown on titanium separately and responded to S. oralis biofilm challenge. The cell condition of HGF was dramatically impaired after 4 hours showing a transcriptional inflammatory and stress response. In contrast, S. oralis challenge induced only transcriptional inflammatory response in HGEp with their cell condition remaining unaffected. Subsequently, HGF were susceptible compared to HGEp. The proinflammatory IL-6 was attenuated in HGF and CXCL8 in HGEp indicating a general tissue-protective role of S. oralis, forasmuch as the HGF are not exposed. In conclusion, an intact implant-mucosa interface is a prerequisite so that commensal biofilms can promote homeostasis for tissue protection.

2020-06-17 | GSE134481 | GEO

Transcriptome profiling of Lactococcus lactis subsp. cremoris CECT 8666 in response to agmatine

2015-11-09 | GSE74808 | GEO

Transcriptome profiling of Lactococcus lactis subsp. cremoris CECT 8666 in response to agmatine

Project description:The goal was to determine the effect of agmatine on the trancriptional profile of L. lactis CECT 8666 strain. For that we compared the expression profile of L. lactis CECT 8666 cells grown in culture medium supplemented with 20 mM agmatine with the expression profile of L. lactis CECT 8666 cells grown in culture medium without agmatine. L. lactis CECT 8666 cells grown in GalM17 medium (reference) compared to L. lactis CECT 8666 cells grown in GalM17 medium supplemented with 20 mM agmatine (test).

2015-11-09 | E-GEOD-74808 | biostudies-arrayexpress

Streptococcus oralis subsp. oralis strain:SN51445

Project description:Streptococcus oralis subsp. oralis that lack SRRPs

| PRJNA635656 | ENA

Streptococcus oralis

Project description:Streptococcus oralis overview

| PRJNA38803 | ENA

Methanobrevibacter oralis

Project description:Methanobrevibacter oralis overview

| PRJNA320905 | ENA

Hoylesella oralis

Project description:Prevotella oralis overview