Project description:Intracranial mesenchymal tumors, FET-CREB fusion-positive (ICMT ) show fusions involving FET RNA-binding protein family gene (EWSR1 or FUS) and CREB family of transcription factors (ATF1, CREB1 or CREM). The methylation characteristics and clinical behavior of this important tumor type require further characterization. We study the methylation profiles of 81 ICMT cases (61 newly profiled cases and 20 cases from publicly available sources). ICMT showed a relatively distinct methylation signature compared to related tumors. We confirmed the prior description of two distinct subgroups of ICMT (subclasses A and B).
Project description:In this study, we screened a cohort of 57 paediatric brain tumours, with a wide range of pathologies to identify gene expression profiles