Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Increased expression of Ectodysplasin A2 Receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark

ABSTRACT: Increased expression of Ectodysplasin A2 Receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark

PROVIDER: PRJEB63363 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR11584201.fastq.gz	Fastqsanger.gz
	ERR11584202.fastq.gz	Fastqsanger.gz
	ERR11584203.fastq.gz	Fastqsanger.gz
	ERR11584204.fastq.gz	Fastqsanger.gz
	ERR11584205.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Increased expression of Ectodysplasin A2 Receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark (Murine Myotubes)

Project description:We report that increased mRNA-expression of Ectodysplasin-A2-Receptor (EDA2R) is the most remarkable aging-associated transcriptional perturbation in humans and that its induction is confirmed in murine-models of Hutchinson-Gilford progeria syndrome and in other species. Up-regulation of EDA2R occurs in all solid-tissues and is complemented by the progressive transcriptional increase of its ligand in bloodstream. Strengthening of EDA2R/EDA-A2 signaling may exacerbate inflammation in ageing individuals which might be prevented by EDA2R/EDA-A2 blockade.

2024-09-13 | E-MTAB-14234 | biostudies-arrayexpress

Increased expression of Ectodysplasin A2 Receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark (Murine Myotubes)

Project description:Increased expression of Ectodysplasin A2 Receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark (Murine Myotubes)

| PRJEB77408 | ENA

Increased expression of Ectodysplasin A2 Receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark (Human Myoblasts)

Project description:Increased expression of Ectodysplasin A2 Receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark (Human Myoblasts)

| PRJEB77671 | ENA

Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses.

Project description:Intensive efforts have been made to identify features that could serve as biomarkers of aging. Yet, drug-based interventions aimed at lessening the detrimental effects of getting older are lacking. This is largely attributable to tissue-specificity, sex-related differences, and to the difficulty of identifying actionable targets, which continues to pose a significant challenge. Here, we implement a bioinformatics approach revealing that aging-associated increase of the transmembrane Ectodysplasin-A2-Receptor is a prominent tissue-independent alteration occurring in humans and other species, and is particularly pronounced in models of accelerated aging. We show that strengthening of the Ectodysplasin-A2-Receptor signalling axis in myogenic precursors and differentiated myotubes suffices to trigger potent parainflammatory responses, mirroring aspects of aging-driven sarcopenia. Intriguingly, obesity, insulin-resistance, and aging-related comorbidities, such as type-2-diabetes, result in heightened levels of the Ectodysplasin-A2 ligand. Our findings suggest that targeting the Ectodysplasin-A2 surface receptor represents a promising pharmacological strategy to mitigate the development of aging-associated phenotypes.

| S-EPMC11847917 | biostudies-literature

Paracoccus sp. A2 strain:A2 | isolate:A2

Project description:Paracoccus sp. A2 strain:A2 | isolate:A2 Genome sequencing and assembly

| PRJNA1291446 | ENA

Winogradskyella sp. A2 strain:A2

Project description:Winogradskyella sp. A2 strain:A2 Genome sequencing

| PRJNA1168126 | ENA

Halohasta sp. A2 strain:A2

Project description:Halohasta sp. A2 strain:A2 Genome sequencing

| PRJNA911575 | ENA

Gluconacetobacter sp. A2 strain:A2

Project description:Gluconacetobacter sp. A2 strain:A2 Clone ends