Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genomic epidemiology of the 2022-2023 cholera outbreak in Lebanon

ABSTRACT: Genomic epidemiology of the 2022-2023 cholera outbreak in Lebanon

PROVIDER: PRJEB65303 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR11867508_1.fastq.gz	Fastqsanger.gz
	ERR11867508_2.fastq.gz	Fastqsanger.gz
	ERR11867509_1.fastq.gz	Fastqsanger.gz
	ERR11867509_2.fastq.gz	Fastqsanger.gz
	ERR11867510_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 68

Similar Datasets

An unusual two-strain cholera outbreak in Lebanon, 2022-2023: a genomic epidemiology study.

Project description:Cholera is a life-threatening gastrointestinal infection caused by a toxigenic bacterium, Vibrio cholerae. After a lull of almost 30 years, a first case of cholera was detected in Lebanon in October 2022. The outbreak lasted three months, with 8007 suspected cases (671 laboratory-confirmed) and 23 deaths. In this study, we use phenotypic methods and microbial genomics to study 34 clinical and environmental Vibrio cholerae isolates collected throughout this outbreak. All isolates are identified as V. cholerae O1, serotype Ogawa strains from wave 3 of the seventh pandemic El Tor (7PET) lineage. Phylogenomic analysis unexpectedly reveals the presence of two different strains of the seventh pandemic El Tor (7PET) lineage. The dominant strain has a narrow antibiotic resistance profile and is phylogenetically related to South Asian V. cholerae isolates and derived African isolates from the AFR15 sublineage. The second strain is geographically restricted and extensively drug-resistant. It belongs to the AFR13 sublineage and clusters with V. cholerae isolates collected in Yemen. In conclusion, the 2022-2023 Lebanese cholera outbreak is caused by the simultaneous introduction of two different 7PET strains. Genomic surveillance with cross-border collaboration is therefore crucial for the identification of new introductions and routes of circulation of cholera, improving our understanding of cholera epidemiology.

| S-EPMC11322537 | biostudies-literature

Acinetobacter baumannii outbreak 2022-2023

Project description:Acinetobacter baumannii outbreak 2022-2023

| PRJEB62407 | ENA

Project description:Genomic epidemiology of the 2022-2023 cholera outbreak in Lebanon

| PRJNA1013428 | ENA

Hainan cholera outbreak

Project description:Genomic analysis of Hainan cholera outbreak

| PRJEB8241 | ENA

Oral delivery of a cholera toxin-binding protein protects against diarrhoea in experimental cholera

Project description:Oral cholera vaccines (OCVs) have become important components of strategies for cholera control, but the demand for OCVs has outstripped the supply2–4. There is a need for new cholera control measures for the one billion people living in cholera endemic regions5. The use of orally delivered single-domain antibodies has been proposed as a potential approach for the control of gastrointestinal pathogens6. Here, we describe the development of an orally deliverable bivalent VHH construct (BL3.2) that binds to the B-subunit of cholera toxin (CTXB). The epitope of CTXB for binding molecule BL3.2 was mapped by Hydrogen Deuterium Exchange HDX

2025-02-24 | PXD057713 | Pride

The 2016-2017 Yemen cholera outbreak strain

Project description:The 2016-2017 Yemen cholera outbreak strain

| PRJEB24611 | ENA

Vibrio Cholerae Dhaka 2022-2023

Project description:Vibrio Cholerae Dhaka 2022-2023

| PRJEB83967 | ENA

Icelandic groundwater metabarcoding 2022 2023

Project description:Icelandic groundwater metabarcoding 2022 2023 Raw sequence reads

| PRJNA1347764 | ENA

Genomic Epidemiology of Invasive Group A Streptococcus Infections in Argentina during 2023

Project description:Genomic Epidemiology of Invasive Group A Streptococcus Infections in Argentina during 2023