Serrati
Ontology highlight
ABSTRACT:
PROVIDER: PRJEB65988 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Opportunistic bacterial pathogens require effective mechanisms to compete with other bacteria and to switch between host and environment-adapted states. The Type VI secretion system (T6SS) occurs widely in Gram-negative bacteria and mediates efficient killing of neighbouring competitors. Here we describe the distribution of T6SSs across the genus Serratia and report the unexpected discovery that a highly-conserved antibacterial T6SS is differentially active between closely-related clinical isolates of Serratia marcescens. By combining genomic and experimental approaches, we identified a genus-core two-component system which controls T6SS activity and is subject to very frequent inactivating mutations, exclusively in clinically-derived isolates of S. marcescens. This regulatory system controls a number of lifestyle-related traits at transcriptional and post-translational levels, including T6SS activity, antibiotic production, motility and adhesion. Our data support a model whereby this system represents a conserved, modular switch from sessile to pioneering and aggressive behaviour, which is subject to strong selection pressure in the clinical environment.
2025-01-29 | GSE273522 | GEO
Project description:The study consists of analyzing the proteomic profile of a multiresistant bacterial strain, Serratia marcescens (Sm36), after it is challenged to grow in an environment in the presence of Meropenem, an antimicrobial considered broad-spectrum and widely used for the treatment of Healthcare-Associated Infections.
2025-01-03 | PXD059425 | Pride
Project description:Methicillin-resistant Staphylococcus aureus (MRSA) is the causative agent of serious hospital- and community-associated infections. Due to the global rise in community-associated MRSA, the respective lineages are increasingly introduced into hospitals. This raises the question whether and, if so, how they adapt to this new environment. The present study was aimed at investigating how MRSA isolates of the USA300 lineage, infamous for causing infections in the general population, have adapted to the hospital environment. To this end, a collection of community- and hospital-associated USA300 isolates was compared by RNA-sequencing. Here we report that merely 460 genes were differentially expressed between these two epidemiologically distinct groups, including genes for virulence factors, oxidative stress responses and the purine, pyrimidine and fatty acid biosynthetic pathways. Differentially regulated virulence factors included leukotoxins and phenol-soluble modulins, implicated in staphylococcal escape from immune cells. We therefore investigated the ability of the studied isolates to survive internalization by human neutrophils. This showed that the community-associated isolates have the highest neutrophil-killing activity, while the hospital-associated isolates are better adapted to intra-neutrophil survival. Importantly, the latter trait protects internalized staphylococci against a challenge with antibiotics. We therefore conclude that prolonged intra-neutrophil survival serves as a relatively simple early adaptation of S. aureus USA300 to the hospital environment where antibiotic pressure is high.
2016-11-02 | GSE89394 | GEO
Project description:Serratia symbiotica in the Aphid Natural Environment
| PRJNA723024 | ENA
Project description:Disinfectant-resistant Serratia marcescens in a Hungarian hospital
| PRJEB65431 | ENA