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MYCN regulated miRNAs

ABSTRACT: MYCN regulated miRNAs

PROVIDER: PRJEB6787 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR569584.fastq.gz	Fastqsanger.gz
	ERR569585.fastq.gz	Fastqsanger.gz
	ERR569586.fastq.gz	Fastqsanger.gz
	ERR569587.fastq.gz	Fastqsanger.gz
	ERR569588.fastq.gz	Fastqsanger.gz

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MYCN regulated miRNAs

Project description:miRNAs which are differentially expressed upon MYCN overexpression (1h, 4h and 24h after induction) in a neuroblastoma line were detected using deep sequencing.

2015-07-24 | E-MTAB-2787 | biostudies-arrayexpress

Identification of genes regulated by MYCN in retinoblastoma (RB) cell line, Y79.

Project description:To determine the downstream genes regulated by MYCN in RB, MYCN was silenced in Y79 cell line, which expressed hign levels of MYCN, using two lentiviral shRNA constructs targetting MYCN.

2021-10-14 | GSE168903 | GEO

Transcriptional programs regulated by MYCN in liver tumorigenesis

Project description:Transcriptional programs regulated by MYCN in liver tumorigenesis

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RNA-sequencing analysis to identify genes regulated by MYCN in neuroblastoma cell line SHEP by MYCN overexpression

Project description:In this study we identified genes regulated by MYCN in SHEP cells

2023-10-19 | GSE208422 | GEO

RNA-sequencing analysis to investigate genes regulated by HAND2 and MYCN in LAN5 cells

Project description:In this study we identified genes regulated by HAND2 or MYCN or both MYCN and HAND2 in LAN5 cells.

2023-03-29 | GSE183636 | GEO

RNA-sequencing analysis to investigate genes regulated by HAND2 and MYCN in IMR32 cells

Project description:In this study we identified genes regulated by HAND2 or MYCN or both MYCN and HAND2 in IMR32 cells.

2023-03-29 | GSE183609 | GEO

Transcriptional programs regulated by MYCN in liver tumorigenesis

Project description:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death, often diagnosed at advanced stages and characterized by high recurrence rates. While chronic liver inflammation and metabolic dysfunction are recognized contributors to tumorigenesis, the molecular mechanisms linking early microenvironmental stress to malignant transformation remain poorly understood. MYCN, a proto-oncogenic transcription factor, has emerged as a potential biomarker of cancer stemness, yet its functional role in hepatocarcinogenesis is unclear. Here, we applied CUT&RUN-seq analysis and integrated the data with RNA-seq to investigate the direct transcriptional impact of MYCN in liver tumorigenesis. Transcriptomic profiling revealed that MYCN-driven tumors exhibit features of human HCC subtypes enriched in stress-adaptive gene programs. We found genes with upstream MYCN binding showed significantly greater expression changes between tumor and non-tumor samples, suggesting that MYCN binding in promoter-proximal regions has a stronger influence on transcriptional regulation. Pathway analysis revealed significant enrichment in pathways related to cytoskeletal organization, cell motility, and membrane dynamics, all of which are central to intercellular interactions and tumor microenvironment remodeling, indicating that MYCN regulates pathways contributing to tumor microenvironment remodeling and cellular interactions.

2025-07-19 | GSE302484 | GEO

Effects of MYCN knockdwon on miRNA expression in neuroblastoma cells

Project description:Global miRNAs expression profilling of SK-N-BE(2)-C cells after dsRNA-mediated knockdown of MYCN To identify MYCN-associated miRNAs, we carried out a small RNA-seq on MYCN knockdown in SK-N-BE(2)-C cells to profile the miRNA expression.

2016-05-16 | E-GEOD-72721 | biostudies-arrayexpress

Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation

Project description:Neuroblastomas are tumors of the developing peripheral sympathetic nervous system, which originates from the neural crest. Twenty percent of neuroblastomas show amplification of the MYCN oncogene, which correlates with poor prognosis. The MYCN transcription factor can activate and repress gene expression. To broaden our insight in the spectrum of genes down-regulated by MYCN, we generated gene expression profiles of the neuroblastoma cell lines SHEP-21N and SKNAS-NmycER, in which MYCN activity can be regulated. In this study, we show that MYCN suppresses the expression of Dickkopf-1 (DKK1) in both cell lines. DKK1 is a potent inhibitor of the wnt/beta-catenin signalling cascade, which is known to function in neural crest cell migration. We generated a DKK1 inducible cell line, IMR32-DKK1, which showed impaired proliferation upon DKK1 expression. Surprisingly, DKK1 expression did not inhibit the canonical wnt/beta-catenin signalling, suggesting a role of DKK1 in an alternative route of the wnt pathway. Gene expression profiling of two IMR32-DKK1 clones showed that only a few genes, amongst which SYNPO2, were up-regulated by DKK1. SYNPO2 encodes an actin-binding protein and was previously found to inhibit proliferation and invasiveness of prostate cancer cells. These results suggest that MYCN might stimulate cell proliferation by inhibiting the expression of DKK1. DKK1 might exert part of its growth suppressive effect by induction of SYNPO2 expression. Keywords: DKK1, MYCN, neuroblastoma, Dickkopf

2007-08-24 | GSE8066 | GEO

TAL1 regulated miRNAs

Project description:miRNA profiling of Jurkat T-ALL cells after knockdown with two control shRNAs and two shRNAs targeting TAL1 to identify miRNAs that are regulated by TAL1

2013-06-15 | GSE46957 | GEO

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