Ontology highlight
ABSTRACT:
PROVIDER: PRJEB73276 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| ERR12918000.fastq.gz | Fastqsanger.gz | |||
| ERR12917201.fastq.gz | Fastqsanger.gz | |||
| ERR12918001.fastq.gz | Fastqsanger.gz | |||
| ERR12917202.fastq.gz | Fastqsanger.gz | |||
| ERR12918002.fastq.gz | Fastqsanger.gz |
Items per page: 5 1 - 5 of 180 |
Similar Datasets
Project description:Gene expression profile of human CD34+-derived erythoblast infected by the human malaria parasite Plasmodium falciparum
2025-01-24 | E-GEOD-24849 | ExpressionAtlas
Project description:Gene expression data from whole-blood collected from Kenyan children with Plasmodium falciparum malaria infection at acute hospital admission (n=15) and at convalescence (n=9). A clinical history design type is where the organisms clinical history of diagnosis, treatments, e.g. vaccinations, surgery etc. Disease State: with Plasmodium falciparum malaria infection at acute hospital admission and at convalescence
2016-02-15 | GSE35860 | GEO
Project description:Gene expression data from whole-blood collected from Kenyan children with Plasmodium falciparum malaria infection at acute hospital admission (n=15) and at convalescence (n=9). A clinical history design type is where the organisms clinical history of diagnosis, treatments, e.g. vaccinations, surgery etc. Disease State: with Plasmodium falciparum malaria infection at acute hospital admission and at convalescence clinical_history_design
2016-02-15 | E-GEOD-35860 | biostudies-arrayexpress
Project description:Gene expression data from whole-blood collected from healthy Vietnamese subjects (n=8) or from patients admitted to hospital with acute uncomplicated (n=9) or complicated (n=20) Plasmodium falciparum malaria infection. A clinical history design type is where the organisms clinical history of diagnosis, treatments, e.g. vaccinations, surgery etc. Disease State: patient with complicated or uncomplicated Plasmodium falciparum malaria infection or Healthy control clinical_history_design
2016-02-15 | E-GEOD-35858 | biostudies-arrayexpress
Project description:Gene expression data from whole-blood collected from healthy Vietnamese subjects (n=8) or from patients admitted to hospital with acute uncomplicated (n=9) or complicated (n=20) Plasmodium falciparum malaria infection. A clinical history design type is where the organisms clinical history of diagnosis, treatments, e.g. vaccinations, surgery etc. Disease State: patient with complicated or uncomplicated Plasmodium falciparum malaria infection or Healthy control
2016-02-15 | GSE35858 | GEO
Project description:Plasmodium falciparum infection can trigger high levels of inflammation that lead to fever and sometimes severe disease. People living in malaria-endemic areas gradually develop resistance and control both parasite numbers and the inflammatory response. Adaptive Natural Killer (NK) cells correlate with reduced parasite load and protection from symptoms. However, additional NK cell immunoregulatory roles may lower inflammation and reduce fever induction. We previously found that murine NK cell production of IL-10 can protect mice from experimental cerebral malaria. Human NK cells can also secrete IL-10, but it was unknown what NK cell subsets produce IL-10 and if this is affected by malaria infection history. Here, we show that NK cells from subjects with malaria history make significantly more IL-10 than subjects with no malaria history. We then determined the proportions of NK cells that are cytotoxic and produce interferon g (IFNg) and/or IL-10 and identified a signature of adaptive and checkpoint molecules on IL-10 producing NK cells. Lastly, we find that co-culture with primary monocytes, Plasmodium-infected RBCs, and antibody induces IL-10 production by NK cells. These data suggest that NK cells may help with protection from malaria because of IL-10 induction.
2025-05-06 | GSE266970 | GEO
Project description:Ancient genomes from the Irish Mesolithic and Neolithic shed light on prehistoric social and political structure.
| PRJEB36854 | ENA
Project description:Abstract: The antimalarial activity of the antibiotic thiostrepton has long been attributed to inhibition of apicoplast protein synthesis through binding of apicoplast ribosomal RNA. However, the kinetics of parasite death upon thiostrepton treatment differ from those seen for other inhibitors of apicoplast housekeeping functions. We have analysed global changes in gene expression of the malaria parasite, Plasmodium falciparum, in an attempt to shed light on the responses of the parasite to this drug. Our results indicate a delay in gene expression profiles of thiostrepton-treated parasites. A small number of genes appear to be regulated outside of this trend; our data suggest a response from genes encoding components of the mitochondrial translational machinery, while little response is seen from genes encoding apicoplast-targeted proteins. Our findings are consistent with an effect of thiostrepton on mitochondrial protein synthesis, and thus warrant a re-evaluation of the target of thiostrepton in Plasmodium. They also provide some suggestion of mitochondrion – nucleus signalling in the parasite. 3 biological replicates each for treated and untreated: control (1/2000 DMSO) and LD70 thiostrepton, respectively
2011-06-30 | E-GEOD-28701 | biostudies-arrayexpress
Project description:RNA-seq of human pluripotent cells with ancient ADSL
2025-01-23 | E-MTAB-7979 | ExpressionAtlas