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SOX7 and SOX17 DNA binding in baseline HUVEC

ABSTRACT: SOX7 and SOX17 DNA binding in baseline HUVEC

PROVIDER: PRJEB74666 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR12865437_1.fastq.gz	Fastqsanger.gz
	ERR12865437_2.fastq.gz	Fastqsanger.gz
	ERR12865438_1.fastq.gz	Fastqsanger.gz
	ERR12865438_2.fastq.gz	Fastqsanger.gz
	ERR12865439_1.fastq.gz	Fastqsanger.gz

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SOX7 and SOX17 DNA binding in baseline HUVEC

Project description:SOXF transcription factors are highly relevant for endothelial biology, yet comprehensive binding data of the endogenous proteins in endothelial cells has not previously been published. We used CUT&RUN to determine the binding patterns of endogenous SOX7 and SOX17 in baseline human umbilical vein endothelial cells (HUVEC).

2025-03-27 | E-MTAB-13999 | biostudies-arrayexpress

HUVEC gene profile after Sox7/Sox17 siRNA silencing

Project description:To find out the target of transcription factor Sox7 and Sox17, DNA microarray analysis was performed with RNA from Sox7 and Sox17 knockdown HUVECs.

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Project description:Analysis of the expression of F9 cells after knockdown of Sox7 and Sox17 during their primitive endoderm differnetiation induction with retinoic acid. Results provide information on the endodermal gene expression program regulated by Sox7 and Sox17. Sox7 Sox17 double KD vs. control in F9 cells

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Project description:Glioblastoma multiforme (GBM) is a highly aggressive and vascularized malignant brain tumor. SoxF transcription factors consisting of Sox7, Sox17, and Sox18 are expressed specifically in endothelial cells (ECs) and contribute to vascular morphogenesis. While the role of Sox17 was found in subcutaneous ectopic tumors, Sox7 has not been studied in the context of tumor angiogenesis. Here, we investigated gene expression profile of RNA analysis of Sox7- and Sox17-deficient mouse endothelial cells from high grade glioma using RNA sequencing to validate molecular characteristics of Sox7 and Sox17 in high grade glioma.

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Transcription profiling by array of human embryonic stem cells over-expression SOX7 and SOX17

Project description:This study aimed to understand the transcriptional networks regulating endoderm specification from HESC and therefore explored the phenotype of CA1 and CA2 HESC constitutively over-expressing SOX7 or SOX17. Cell lines were created using an inducible construct whereby clonal populations containing transgene integration are selected by Neomycin resistance without expressing of the gene of interest (NoCre controls). Transgene expression is induced via Cre-mediated recombination and selected for puromycin resistance (SOX O/E). The phenotype of the resulting cells suggests that SOX7 expressing HESC represent stable extraembryonic endoderm progenitors, while SOX17 expressing HESC represent early definitive endoderm progenitors. Both in vitro and in vivo SOX7 expressing HESC are restricted to the extraembryonic endoderm lineage, while SOX17 expressing HESC demonstrate mesendodermal specificity. In vitro, SOX17 expressing HESC efficiently produce mature definitive endoderm derivatives. The molecular phenotype of the resulting SOX7 and SOX17 expressing HESC was characterized by microarray analysis Experiment Overall Design: Total RNA was extracted from confluent monolayer cultures of SOX7 over-expressing HESC, SOX17 over-expressing HESC, and their respective control parental HESC lines (designated NoCre Sox7 and NoCre Sox17).

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Gene expression analysis of F9 cells double knock-down for Sox7 and Sox17

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Global gene expression from SOX7 and SOX17 over-expressing human embryonic stem cells (CA1 and CA2 lines)

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Project description:We identified Sox17 as a novel angiogenic transcription factor in the context of tumor. Our data revealed that Sox17 promotes tumor angiogenesis and tumor vessel abnormality. We found that Sox17 is specifically expressed in tumor endothelial cells within tumors. Our study elucidates a novel transcriptional regulation for tumor angiogenesis

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Transcriptional regulation of Sox17 in HUVEC

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SOX7 ChIP-seq in HUVECs

Project description:We investigated SOX7 binding events on the chromatin under basal conditions in human umbilical vein endothelial cells, upon overexpression of human SOX7-mCherry and immunoprecipitating mCherry. Cells overexpressing only the mCherry tag were used as negative control condition, and peaks called here were substracted from the SOX7-mCherry peaks.

2017-02-01 | E-MTAB-4480 | biostudies-arrayexpress

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