Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ATAC-seq of C57BL/6J, Castaneus, and Caroli mouse livers and C57BL/6J liver tumours

ABSTRACT: ATAC-seq of C57BL/6J, Castaneus, and Caroli mouse livers and C57BL/6J liver tumours

PROVIDER: PRJEB76291 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

ATAC-seq of C57BL/6J, Castaneus, and Caroli mouse livers and C57BL/6J liver tumours

Project description:Liver samples were isolated from postnatal day 15 (P15) untreated mice and then flash frozen: Mus musculus musculus (C57BL/6J), Mus musculus castaneus (CAST), and Mus caroli (CAROLI). DEN-induced liver tumours and background liver tissue were collected from 37-week old C57BL/6J mice. ATAC-seq was performed to identify the open regions of the genome.

2026-05-15 | E-MTAB-14144 | biostudies-arrayexpress

Total RNA-sequencing of liver tumours and non-tumour liver tissue from five strains of mice and rat

Project description:This study aimed to investigate transcriptional differences between liver tumours that were chemically-induced in five strains and species of mouse and rat. Male mice (Mus musculus domesticus C3H/HeOuJ and C57BL/6J, Mus musculus castaneus CAST/EiJ, and Mus Caroli CAROLI/EiJ) and rats (Fischer F344) were treated with diethylnitrosamine (DEN) to induce liver tumours. After tumour dissection, genomic DNA and RNA were simultaneously isolated and purified for library preparation and sequencing. Additional liver tissue samples were collected and processed in parallel: untreated liver from infant mice (15-day old, P15) and juvenile rats (56-day old, P56); untreated adult liver tissue; DEN-exposed adult liver tissue; spontaneous liver tumours.

2026-05-07 | E-MTAB-16391 | biostudies-arrayexpress

LAKTP_MTO orthotopic primary caecum tumours from Galunisertib-treated C57BL/6J mice

Project description:Mouse tumour organoids (MTOs) derived from a compound mutant (LAKTP) intestinal cancer model were orthoptopically transplanted into syngeneic C57BL/6J mice. Tumour-bearing mice were treated with TGF-beta inhibitor Galunisertib or vehicle control. Whole tumour mRNA was extracted from primary tumours and expression profiling was performed with the objective to characterize the tumour microenvironment (TME). As a TGF-beta-activated TME has been associated to a poor prognosis and the CRC consensum molecular subtype CMS4, and the mouse model was found to have such an activated TME, we used the array data to classify these tumours in this mouse model system as CMS4-like. Furthermore, treatment with TGF-beta inhibitor reduced the fibroblast- and T cell-specific TGF-beta response signatures, also associated to poor prognosis in human CRC. This treatment was associated to a strong reduction/prevention of liver metastasis, as well as a reduction of primary tumour (and local carcinomatosis) size.

2018-02-12 | GSE103562 | GEO

Small intestinal epithelial cells from C57Bl/6J mice

Project description:Total proteome from sorted primary intestinal epithelial cells isolated from the small intestines of 4 C57Bl/6J mice

2024-10-02 | PXD055546 | Pride

Mus musculus strain:C57BL/6J

Project description:C57BL/6J Transcriptome

| PRJNA699121 | ENA

C57BL/6J

Project description:Faecal microbiota composition across different C57BL/6J inbred mice generations

| PRJNA335681 | ENA

Anthoscopus caroli

Project description:Anthoscopus caroli

| PRJNA919788 | ENA

Campethera caroli

Project description:Campethera caroli

| PRJNA1121901 | ENA

RNA sequencing of C57BL/6J mice, heterozygous for knockout of Hnrnph1 gene, as well as C57BL/6J mice controls

Project description:Previous studies of congenic lines of C57BL/6J-DBA/2J mice compared to C57BL/6 mice revealed a 0.23 QTL for sensitivity to methamphetamine on chromosome 11, which contains two protein coding genes, Rufy1 and Hnrnph1. Subsequent transcription activator-like effector nucleases (TALENs)-mediated introduction of frameshift deletions in the first coding exon of one copy of Hnrnph1 of C57BL/6J mice, revealed comparable association to phenotype. Analysis of the transcriptome and splicesome between these Hnrnph1 heterozygous knockouts and C57BL/6J mice revealed genome-wide differentially expression and exon usage of more than 1000 genes in either.

2017-02-01 | GSE76929 | GEO

Platelet proteomic analysis of exercising and standard-housed aged C57BL/6J mice

Project description:Platelets were isolated from standard-housed and exercising (4 days and 28 days) 18-month-old C57BL/6J mice and mass spectrometry performed. This analysis revealed differential proteomic signatures between platelets from exercsising and standard-housed mice.

2023-08-18 | PXD041701 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data