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RELA and RELC differently modulate transcriptional profile of MT-2 cells

ABSTRACT: RELA and RELC differently modulate transcriptional profile of MT-2 cells

PROVIDER: PRJEB77024 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR13332900_1.fastq.gz	Fastqsanger.gz
	ERR13332900_2.fastq.gz	Fastqsanger.gz
	ERR13332901_1.fastq.gz	Fastqsanger.gz
	ERR13332901_2.fastq.gz	Fastqsanger.gz
	ERR13332902_1.fastq.gz	Fastqsanger.gz

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RELA and RELC differently modulate transcriptional profile of MT-2 cells

Project description:To investigate the effects of NFKB signaling, RNA-seq analysis was performed on both Jurkat and MT-2 cells. It was observed that either RELA or RELC knockout could alter the gene expression profile in MT-2 cells compared to Jurkat cells.Gene expression profiles of RELA-C knockout Jurkat cells were compared to the mock edited Jurkat cells. On the other hand, it was hypothesized that the gene expression profile of MT-2 cells can be more drastically altered by RELA or RELC knockout compared to RELB knockout.

2024-08-01 | E-MTAB-14212 | biostudies-arrayexpress

NFKB1 and NFKB2 differently modulate transcriptional profile of MT-2 cells

Project description:NFKB1 and NFKB2 differently modulate transcriptional profile of MT-2 cells

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NFKB1 and NFKB2 differently modulate transcriptional profile of MT-2 cells

Project description:To investigate the effects of NFKB signaling, RNA-seq analysis was performed on both Jurkat and MT-2 cells. It was observed that either NFKB1 or NFKB2 knockout could alter the gene expression profile in MT-2 cells compared to Jurkat cells. Gene expression profiles of NFKB1/NFKB2 knockout Jurkat cells were compared to the mock edited Jurkat cells. On the other hand, it was hypothesized that the gene expression profile of MT-2 cells can be more drastically altered by NFKB1 or NFKB2 knockout. NFKB2 knockout MT-2 cells exhibited a unique gene expression profile compared to those of NFKB1 knockout MT-2 cells and mock edited MT-2 cells.

2023-11-01 | E-MTAB-13408 | biostudies-arrayexpress

Human RELA haploinsufficiency results in autosomal dominant chronic mucocutaneous ulceration: the transcriptional profile of RelA haploinsufficient patients

Project description:The treatment of chronic mucocutaneous ulceration is challenging and only some patients respond selectively to inhibitors of tumor necrosis factor-alpha (TNF-a). TNF-a activates opposing pathways leading to caspase-8-mediated apoptosis as well as NF-kB-dependent cell survival. We investigated the etiology of autosomal dominant mucocutaneous ulceration in a family whose proband was dependent on anti-TNF-a therapy for sustained remission. A heterozygous mutation in RELA (NM_021975: c.559+1G>A), encoding the NF-kB subunit RelA (p65), segregated with the disease phenotype and resulted in RelA haploinsufficiency. The patients’ fibroblasts exhibited increased apoptosis in response to TNF-a, impaired NF-kB activation, and defective expression of NF-B-dependent anti-apoptotic genes. We show that Rela+/- mice have similarly impaired NF-kB activation, develop cutaneous ulceration from TNF-a exposure, and exhibit severe dextran sodium sulfate-induced colitis ameliorated by TNF-a inhibition. These findings demonstrate an essential contribution of biallelic RELA expression in protecting stromal cells from TNF-a-mediated cell death, thus delineating the mechanisms driving the effectiveness of TNF-a inhibition in this disease.

2017-05-09 | GSE98624 | GEO

MT alignment

Project description:Alignement including 83 MT AA sequences and 2 reference sequences, rCRS and RSRS

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Rela

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