Project description:Metagenomic reconstruction of prokaryotes and eukaryotes using shotgun sequenced sedimentary ancient DNA in Upper Lake Constance

| PRJEB76926 | ENA

The ecological status of benthic environment in a Norwegian fjord: impact of aquaculture and jellyfish blooms

Project description:The combined effect of aquaculture and jellyfish blooms in a Norwegian fjord

| PRJEB32422 | ENA

Sedimentary ancient DNA shotgun data Lake Bolshoi Toko

Project description:Sedimentary ancient DNA shotgun data Lake Bolshoi Toko sediment core

| PRJEB80642 | ENA

Non-disruptive in vitro monitoring of cellular states with cell-free DNA methylation

Project description:Regenerative cell therapies and stem-based in vitro models all aspire the approximation of a given start cell to an alternate (often more mature) cell state. However, ‘monitoring’, hence controlling, such a dynamic process requires disruption of the precious sample, destroying architecture and introducing variation. Here, we establish real time-compatible, fully non-invasive monitoring of cell fates through simple cell-free DNA medium sampling. We demonstrate that cell-free DNA methylation non-disruptively reveals genome-wide DNA methylation transitions during epigenetic drug treatment in stem cells, and reports the gradual maturation of 3D hepatocytes grown in bioreactors. Our cell-free DNA methylation platform enables monitoring a broad variety of in vitro systems, has implications for the real-time evaluation human therapeutic cells, and the potential to be readily integrated into large-scale bioreactor workflows.

2026-01-29 | GSE293866 | GEO

Sedimentary aDNA, El'ad, Israel

Project description:Sedimentary aDNA, El'ad, Israel

| PRJEB73782 | ENA