Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Deficiency of adenosine deaminase 2 skews adaptive immune repertoires towards specific sets of T and B cell receptors

ABSTRACT: Deficiency of adenosine deaminase 2 skews adaptive immune repertoires towards specific sets of T and B cell receptors

PROVIDER: PRJEB83076 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

New targets of Drosophila adenosine deaminase acting on RNA (dADAR)

Project description:The aim of this experiment is to identify new targets of Drosophila adenosine deaminase acting on RNA (dADAR) by enriching Inosine-containing mRNA (I-mRNA) from wild type (C-S) and dADAR mutant flies and then hybridization with Drosophila cDNA arrays.

2010-06-05 | E-GEOD-529 | biostudies-arrayexpress

New targets of Drosophila adenosine deaminase acting on RNA (dADAR)

2003-07-14 | GSE529 | GEO

Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase

Project description:Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase

| PRJNA1055593 | ENA

Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase I

Project description:Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase I

| PRJNA859809 | ENA

Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase II

Project description:Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase II

| PRJNA1035456 | ENA

Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR)

Project description:Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR)

| PRJNA208619 | ENA

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

Project description:Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

| PRJNA503859 | ENA

Single-cell profiling of T lymphocytes in deficiency of adenosine deaminase 2

Project description:Single-cell profiling of T lymphocytes in deficiency of adenosine deaminase 2

| PRJNA706382 | ENA

Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge

Project description:Aged patients suffer disproportionately increased morbidity and mortality associated with SARS-CoV-2 infection. Despite numerous clinically available vaccines and therapeutics, aged patients remain at increased risk for COVID-19 morbidity. Furthermore, the aged patient population has suboptimal responses to SARS-CoV-2 vaccine antigens. Here, we characterize vaccine-induced responses to SARS-CoV-2 synthetic DNA vaccine antigens in 18-month-old mice and interrogate protection. Aged mice have altered cellular responses, including decreased IFNγ secretion and increased TNFα secretion as compared to young mice. Aged mice had significantly decreased binding and neutralizing antibodies in their serum compared to their young counterparts. Co-immunization with the plasmid-encoded molecular adjuvant adenosine deaminase-1 (pADA) enhanced cellular responses and expanded the breadth of humoral responses in aged mice. pADA co-delivery also altered the gene expression profiles of lymph node lymphocytes in aged animals. Upon challenge pADA co-immunization modestly decreased age-associated morbidity and mortality in ACE2 transgenic and mouse-adapted SARS-CoV-2 challenge models. These data support the use of aged mice as a model for age-associated decreased vaccine immunogenicity and infection-mediated morbidity and mortality in the context of SARS-CoV-2 and provide further support of the use of adenosine deaminase as a molecular adjuvant.

2023-02-28 | GSE217200 | GEO

Adenosine DeAminase-1 (ADA-1) improves Follicular helper T cell function and vaccine response

Project description:Adenosine DeAminase-1 (ADA-1) improves Follicular helper T cell function and vaccine response

| PRJNA389585 | ENA