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Characterization of (broad-host-range) bacteriophages targeting multidrug-resistant E. coli and Shigella spp.: in vitro Potential

ABSTRACT: bacteriophages targeting multidrug-resistant bacteria

PROVIDER: PRJEB83222 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR14231159_1.fastq.gz	Fastqsanger.gz
	ERR14231159_2.fastq.gz	Fastqsanger.gz
	ERR14231160_1.fastq.gz	Fastqsanger.gz
	ERR14231160_2.fastq.gz	Fastqsanger.gz

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Similar Datasets

Characterization of broad-host-range bacteriophages targeting multidrug- resistant E. coli and Shigella spp.: in vitro Potential

Project description:bacteriophages targeting multidrug- resistant pathogens

| PRJEB85437 | ENA

Characterization of broad-host-range bacteriophages targeting multidrug- resistant E. coli and Shigella spp.: in vitro Potential

Project description:bacteriophages targeting multidrug- resistant pathogens_partB

| PRJEB104912 | ENA

Characterization of broad-host-range bacteriophages targeting multidrug- resistant E. coli and Shigella spp.: in vitro Potential

Project description:bacteriophages targeting multidrug- resistant pathogens_partB

| PRJEB104716 | ENA

Bacteriophages isolated from Lake Michigan demonstrate broad host-range across several bacterial phyla.

Project description:BackgroundThe study of bacteriophages continues to generate key information about microbial interactions in the environment. Many phenotypic characteristics of bacteriophages cannot be examined by sequencing alone, further highlighting the necessity for isolation and examination of phages from environmental samples. While much of our current knowledge base has been generated by the study of marine phages, freshwater viruses are understudied in comparison. Our group has previously conducted metagenomics-based studies samples collected from Lake Michigan - the data presented in this study relate to four phages that were extracted from the same samples.FindingsFour phages were extracted from Lake Michigan on the same bacterial host, exhibiting similar morphological characteristics as shown under transmission electron microscopy. Growth characteristics of the phages were unique to each isolate. Each phage demonstrated a host-range spanning several phyla of bacteria - to date, such a broad host-range is yet to be reported. Genomic data reveals genomes of a similar size, and close similarities between the Lake Michigan phages and the Pseudomonas phage PB1, however, the majority of annotated genes present were ORFans and little insight was offered into mechanisms for host-range.ConclusionsThe phages isolated from Lake Michigan are capable of infecting several bacterial phyla, and demonstrate varied phenotypic characteristics despite similarities in host preference, and at the genomic level. We propose that such a broad host-range is likely related to the oligotrophic nature of Lake Michigan, and the competitive benefit that this characteristic may lend to phages in nature.

| S-EPMC4600314 | biostudies-literature

Complete Genome Sequences of Broad-Host-Range Pseudomonas aeruginosa Bacteriophages ΦR18 and ΦS12-1.

Project description:Pseudomonas aeruginosa is an important cause of racehorse keratitis. Bacteriophage therapy has the potential to aid in the prevention and treatment of diseases caused by P. aeruginosa We present here the complete genome sequences of two phages, ΦR18 and ΦS12-1, which exhibit infectivity for a broad range of P. aeruginosa isolates.

| S-EPMC4859162 | biostudies-literature

Two Novel <i>Yersinia pestis</i> Bacteriophages with a Broad Host Range: Potential as Biocontrol Agents in Plague Natural Foci.

Project description:Bacteriophages (phages) have been successfully used as disinfectors to kill bacteria in food and the environment and have been used medically for curing human diseases. The objective of this research was to elucidate the morphological and genomic characteristics of two novel Yersinia pestis phages, vB_YpeM_ MHS112 (MHS112) and vB_YpeM_GMS130 (GMS130), belonging to the genus Gaprivervirus, subfamily Tevenvirinae, family Myoviridae. Genome sequencing showed that the sizes of MHS112 and GMS130 were 170507 and 168552 bp, respectively. A total of 303 and 292 open reading frames with 2 tRNA and 3 tRNA were predicted in MHS112 and GMS130, respectively. The phylogenetic relationships were analysed among the two novel Y. pestis phages, phages in the genus Gaprivervirus, and several T4-like phages infecting the Yersinia genus. The bacteriophage MHS112 and GMS130 exhibited a wider lytic host spectrum and exhibited comparative temperature and pH stability. Such features signify that these phages do not need to rely on Y. pestis as their host bacteria in the ecological environment, while they could be based on more massive Enterobacteriales species to propagate and form ecological barriers against Y. pestis pathogens colonised in plague foci. Such characteristics indicated that the two phages have potential as biocontrol agents for eliminating the endemics of animal plague in natural plague foci.

| S-EPMC9785759 | biostudies-literature

Isolation of bacteriophages against Salmonella spp

Project description:Isolation of bacteriophages against Salmonella spp

| PRJEB90109 | ENA

Aeromonas spp. and their bacteriophages

Project description:Genomic diversity of Latvian Aeromonas spp. isolates and their bacteriophages

| PRJNA1210563 | ENA

Complete genome sequence of a broad-host-range lytic Dickeya spp. bacteriophage ϕD5.

Project description:Little is known about lytic bacteriophages infecting plant-pathogenic Dickeya spp. These bacteria cause economically significant losses in arable crops and ornamental plant production worldwide. At present, there is no effective control of diseases caused by Dickeya spp. A novel bacteriophage, ϕD5, belonging to the family Myoviridae, order Caudovirales, that could be used to control these bacteria was isolated previously. This report provides information on its characterization. The ϕD5 genome consists of 155,346-bp-length double-stranded DNA with a GC content of 49.7 % and is predicted to have 196 open reading frames (ORFs) with an average length of 711 nucleotides each. The ORFs were classified into functional groups, including phage structure, packaging, DNA metabolism, regulation, and additional functions. The phage lifestyle predicted from PHACTS indicated that ϕD5 may be a lytic phage and therefore can efficiently kill plant-pathogenic Dickeya spp.

| S-EPMC4200354 | biostudies-literature

Broad-host-range IncP-1 plasmids and their resistance potential.

Project description:The plasmids of the incompatibility (Inc) group IncP-1, also called IncP, as extrachromosomal genetic elements can transfer and replicate virtually in all Gram-negative bacteria. They are composed of backbone genes that encode a variety of essential functions and accessory genes that have implications for human health and environmental bioremediation. Broad-host-range IncP plasmids are known to spread genes between distinct phylogenetic groups of bacteria. These genes often code for resistances to a broad spectrum of antibiotics, heavy metals, and quaternary ammonium compounds used as disinfectants. The backbone of these plasmids carries modules that enable them to effectively replicate, move to a new host via conjugative transfer and to be stably maintained in bacterial cells. The adaptive, resistance, and virulence genes are mainly located on mobile genetic elements integrated between the functional plasmid backbone modules. Environmental studies have demonstrated the wide distribution of IncP-like replicons in manure, soils and wastewater treatment plants. They also are present in strains of pathogenic or opportunistic bacteria, which can be a cause for concern, because they may encode multiresistance. Their broad distribution suggests that IncP plasmids play a crucial role in bacterial adaptation by utilizing horizontal gene transfer. This review summarizes the variety of genetic information and physiological functions carried by IncP plasmids, which can contribute to the spread of antibiotic and heavy metal resistance while also mediating the process of bioremediation of pollutants. Due to the location of the resistance genes on plasmids with a broad-host-range and the presence of transposons carrying these genes it seems that the spread of these genes would be possible and quite hazardous in infection control. Future studies are required to determine the level of risk of the spread of resistance genes located on these plasmids.

| S-EPMC3590792 | biostudies-literature

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