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Single cell viral tagging of Faecalibacterium prausnitzii reveals rare bacteriophages omitted by other techniques

ABSTRACT: Viral tagging of F. prausnitzii and uncultivated human gut microbes

PROVIDER: PRJEB86846 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	UnVT.fna.gz	Other
	HHC_virome.fna.gz	Other
	CD_virome.fna.gz	Other
	SAGs.fna.gz	Other
	FpVT.fna.gz	Other

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1 - 5 of 371

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Viral Tagging of Faecalibacterium prausnitzii

Project description:Viral tagging of F. prausnitzii

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Single cell viral tagging of <i>Faecalibacterium prausnitzii</i> reveals rare bacteriophages omitted by other techniques.

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Faecalibacterium prausnitzii abrogates immunotherapy toxicity

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Project description:We isolated immune cells from human blood of patients with IBD and non-inflamed controls. We stimulated them with F. prausnitzii EXL01 strain, Cadaverin or lipopolysaccharide (LPS) from Escherichia coli and performed Legendplex, ELISA, flow cytometry, RNA-sequencing (RNAseq), and Seahorse analysis. F. prausnitzii EXL01 strain induced the production of IL-10 in CD14+ monocytes from systemic circulation and intestinal tissue of IBD patients and non-inflamed controls in a direct and dose-dependent manner, without inducing a pro-inflammatory response as compared to LPS stimulation. RNAseq analysis confirmed these results and revealed that F. prausnitzii EXL01 strain differentially affects cell energy metabolism compared to LPS. The anti-inflammatory response induced by F. prausnitzii in monocytes was dependent on mitochondrial activity. F. prausnitzii induces an anti-inflammatory response and rewires energy metabolism in human monocytes, which might explain its beneficial impact on intestinal inflammation and human health in general. These results provide new insight into the mechanisms underlying the anti-inflammatory effects of F. prausnitzii and are crucial for a better understanding of its potential use in the treatment of IBD.

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Anti-inflammatory Effects of the Commensal Bacterium Faecalibacterium prausnitzii analyzed by microarrays

Project description:The human intestinal microbiota plays an essential role in host health. Modifications in its composition and diversity could induce pathologies such as inflammatory bowel diseases (IBD). These diseases are characterized by an unbalanced intestinal microbiota (a process known as dysbiosis) and an altered immune response. Faecalibacterium prausnitzii, the most abundant commensal bacterium in the human intestinal microbiota of healthy individuals (representing more than 5% of the total bacterial population), has been reported to be lower in feces and mucosa-associated microbiota of IBD patients. In addition, we have shown that both F. prausnitzii and its culture supernatant (SN) have anti-inflammatory and protective effects in both acute and chronic colitis models. However, the host molecular mechanisms involved in these anti-inflammatory effects remain unknown. In order to address this issue, we performed DNA chip-based transcriptomic analyses in HT-29 human intestinal epithelial cells stimulated with TNF-a and exposed to F. prausnitzii SN or to BHI (growth medium for F prausnitzii).

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